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- 详细信息
- 文献和实验
- 技术资料
- 克隆性:
多克隆
- 抗体英文名:
AMPKβ Antibody,AMPK,5’-AMP-activated protein kinase,beta-1 subunit,AMP activated protein kinase beta-1 subunit,AMPK beta-1 chain,AMPKb
- 规格:
100 ug
产品名称:AMPKβ抗体|AMPKβ Antibody,AMPK,5’-AMP-activated protein kinase,beta-1 subunit,AMP activated protein kinase beta-1 subunit,AMPK beta-1 chain,AMPKb
【产品形式】:艾美捷为您提供的AMPKβ抗体产品为100 ug 无色溶液,其浓度为0.25 mg/ml,溶解于包含有0.09% (W/V) 叠氮钠的PBS缓冲液中.请将该AMPKβ抗体产品置于-20 ℃冷冻保存,建议分装使用以避免反复冻融.
【背景资料】:AMPK beta-1 chain is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
BioVision的公司总部在美丽的旧金山湾地区,它是全球生命科学公司的领导者.BioVision在开发和研究细胞凋亡检测分析、代谢检测方面具有 卓越的影响力.包括检测各种检测分析试剂盒、相关特色抗体、重组蛋白及细胞因子和酶等多种产品,以及其他创新的研究工具.其产品覆盖细胞凋亡研究、能量代 谢、细胞/组织蛋白提取、氧化应激与损伤、代谢与肥胖症、细胞增殖与毒性、信号转导、干细胞研究等领域.作为多家知名品牌的中国总代理以及中国区域代理, 艾美捷与BioVision一起为研究者们提供最好、最新的细胞生物学研究工具而不断扩大产品及服务质量.
点击:AMPKβ抗体,查看更详细产品说明,更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。
关键词:AMPK,AMPKβ抗体
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文献和实验Analysis of the Role of the AMP-Activated Protein Kinase in the Response to Cellular Stress
The AMP-activated protein kinase (AMPK) is the central component of a protein kinase cascade that is activated by cellular stresses causing ATP depletion and has been referred to as a “fuel gauge” or “metabolic sensor” of the eukaryotic cell
Nature 重磅:林圣彩院士团队七年攻坚!首次破解「神药」二甲双胍作用靶点之谜
截至目前,二甲双胍发挥作用的多种机制被提出。比如说,二甲双胍可以抑制肝细胞线粒体电子传递链的复合物 I,从而降低线粒体氧耗,并抑制三磷酸腺苷(ATP)的生成,使 AMP/ATP 比值升高。增加的 AMP 还可以抑制果糖-1,6-二磷酸酶-1 和腺苷酸环化酶,从而阻止糖异生;二甲双胍也被认为可以改变细胞氧化还原状态,从而增加 NAD+/NADH 比值,抑制糖异生底物的利用。 在二甲双胍的各种潜在效应物中,腺苷酸活化蛋白激酶(AMP-activated protein kinase , AMPK
The ability of prototypical second messenger cyclic AMP (cAMP) to positively control transcription of the somatostatin gene was pivotal to the original identification of the transcription factor cAMP response element-binding protein
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