Lamin B1抗体|Lamin B1 Antibody，L

产品名称：Lamin B1抗体|Lamin B1 Antibody，LMNB1，LMN，LMNB，LMN2，Lamin-B1，ADLD，MGC111419

【产品形式】：艾美捷为您提供的Lamin B1抗体产品为100 ug 无色溶液，其浓度为0.2 mg/ml，溶解于包含有1 mg/ml BSA和1.5 mM 叠氮钠和50%甘油.的PBS缓冲液中.请将该Lamin B1抗体产品置于-20 ℃冷冻保存，建议分装使用以避免反复冻融.

【背景资料】：Lamins are classified into A- and B- type isoforms. Specifically， four distinct lamin isoforms have been identified: A， B1， B2， and C. Lamin A and C are alternatively spliced products of a single gene， whereas lamin B1 and B2 are encoded by distinct genes. During mitosis， lamins are phosphorylated by p34cdc2 and solubilized prior to chromosome condensation and nuclear breakdown. A direct role for lamins in chromosome condensation is suggested by the fact that lamin B binds to specific DNA sequence motifs termed matrix attachment regions （MARs）. Mars mediate the interaction of chromatin with the nuclear matrix. Importantly， some of the same processes that involve mitotic chromosome condensation and nuclear envelop breakdown are also activated during apoptosis. It appears that chromosome condensation during apoptosis is accompanied by degradation of lamin protein. Lamin degradation occurs prior to DNA fragmentation and this degradation is useful as an apoptotic marker.

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点击：Lamin B1抗体，查看更详细产品说明，更多应用、储存、价格、货期等信息请致电400-6800-868垂询BioVision中国区域授权总代理艾美捷科技有限公司。

关键词：LAMIN，Lamin B1抗体