NEDD8 E1 蛋白(人) | NEDD8 E1 prot

【产品形式】：艾美捷为您提供的NEDD8 E1 蛋白(人)形式为25mM HEPES, pH7.5, 150mM NaCl, 1mM DTT

【背景资料】：NEDD8 (neural precursor cell expressed developmentally downregulated gene 8) is an ubiquitin-like protein, with approx. 60% identity to ubiquitin. Conjugation of mature NEDD8 (via its exposed C-terminal glycine76 residue) to specific lysine residues on a number of cellular target proteins via isopeptide bonds, allows NEDD8 to play a critical regulatory role in cell proliferation and development. The NEDD8 conjugation pathway proceeds by a mechanism analogous to that of the ubiquitin conjugation cascade, consisting of a dedicated NEDD8 E1 activating enzyme (a heterodimeric complex consisting of a regulatory subunit APP-BP1 and a catalytic subunit Uba3), E2 conjugating enzymes (Ubc12 and UBE2F) and substrate specific E3 ligases. An increasing number of substrates for NEDDylation, including the tumor suppressors p53 and VHL, have been identified in addition to members of the well-characterised cullin family of proteins, that play a structural role in ubiquitin E3 ligase complexes such as SCF. Recombinant untagged heterodimeric protein complex. Utility in NEDDylation reactions.

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

点击NEDD8 E1 蛋白(人)查看更详细产品说明，更多应用、储存、价格、货期等信息请致电垂询Viva Bioscience中国区域授权总代理艾美捷科技有限公司。