橡黄素 | Quercetin

【产品形式】：Proteasome activator

【背景资料】：Quercetin is a dietary flavonoid showing in vitro a wide range of pharmacologic proprieties, including antioxidant, anti-microbial, anti-inflammatory and anti-proliferative activity. It has been identified as a modulator of proteasome activity, though its inhibitory or activating profile seems to depend to its concentration. At higher, micromolar, levels quercetin acts as an inhibitor of chymotrypsin-like activity whereas at lower doses it has been shown to behave as a proteasome activator that can influence cellular lifespan, survival and viability of HFL-1 primary human fibroblasts. In contrast to the development of 20S proteasome inhibitors, drug-like molecules that can activate or enhance proteasome activity are rare and not well characterised, despite their potential therapeutic benefits for treating specific diseases in which an increase in proteasome activity is thought to be beneficial

英国Viva Bioscience公司是一家研发、生产并销售蛋白降解相关产品的公司。其产品主要用于细胞自噬、泛素化和蛋白酶体研究（也覆盖其他蛋白降解相关的产品），其产品价格合理、质量可靠且具有创新性。目前VIVA Bioscience提供逾460种产品，涉及细胞自噬、蛋白泛素化和讲解相关的所有试剂盒、蛋白、底物以及多种抑制剂、激活剂等全系列产品。作为多家进口品牌的中国区域总代理，艾美捷科技与Viva Bioscience一道为中国科研工作者们提供更好、更新的自噬、泛素化和蛋白酶体等研究工具。

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