丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体

丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体产品标准

浓缩液(1mg/1ml) 亲和纯化抗体

产品应用

WB=1:100-500 Elisa =1:200-1000 IP=1:20-100 IHC=1:100-500 （石蜡切片需做抗原修复）

丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体产品介绍

WNK3 (WNK lysine deficient protein kinase 3) belongs to the serine/threonine protein kinase family. It lacks the almost invariant catalytic lysine in subdomain II, which is important for binding ATP in the catalytic site. A conserved lysine in subdomain I is thought to provide this function. WNK3 activates Na-(K)-Cl cotransporters by increasing their phosphorylation and appears to be a crucial component of the kinase/phosphatase signaling pathway that coordinately regulates the Cl– influx and efflux branches of the SLC12A cotransporter family.
mol wt:192kDa(human), 198kDa(mo), 186kDa(rat)
Other Aliases:
Serine/threonine-protein kinase WNK3; WNK lysine deficient protein kinase 3; Protein kinase with no lysine 3; Protein kinase, lysine-deficient 3; Wnk3; RGD1563131

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丝氨酸/苏氨酸激酶家族成员的基因WNK3抗体