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- 克隆性：
单克隆
- 抗体英文名：
Anti-Mtp53(Mutant ty
- 抗体名：
突变型P53抗体
The widely studied P53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. The level of P53 protein is low in normal cells, but is increased in response to DNA damage or various other cellular distress signals. Overexpression of the P53 transcription factor can induce ether cell cycle arrest or apoptosis through transcriptional regulation of several genes including the cell cycle ingibitor P21, DNA repair gene GADD45, and the apoptotic inducer Bax. P53 has also been shown to induce apoptosis by meas of s direct signaling pathway. P53 directly binds to and acts on several cellular protein involved in various pathway, including c-Abl, basal transcription factor TFIIH and WT1. P53 can be functionally inactivated by mutation, binding to DNA tumor virus encoded proteins, such as SV40 large T antigen, Adenovirus E1B and papilloma virus E6 proteins or as a consequence of its interaction with the oncogene-encoded protein MDM2. This antibody is recognize the Human P53 Core Domain Mutant N235KN239Y.
mol wt:21kDa
Other Aliases:
Chain A, Human P53 Core Domain Mutant N239y; Human P53 Core Domain Mutant N235K, N239Y
xy-0820xy EBNA-3 (Epstein barr nuclear antigens 3)EB病毒编码核蛋白-3
xy-1190xy ECE1(Endothelin Converting Enzyme 1)内皮素转化酶1抗原
xy-1753xy ECE2(Endothelin Converting Enzyme 2)内皮素转化酶2抗原
xy-1754xy ECP(eosinophil cationic protein)mouse rat嗜酸性粒细胞阳离子蛋白抗原
xy-1149xy ED-1 (Ectodermal Dysplasia 1)外胚层发育不良抗原
xy-1755xy EGFL7(EGF-like domain containing protein 7)类表皮生长因子域7抗原
xy-1076xy Egr-1(Early growth response 1)早期反应基因-1/应急反应生长基因1抗原
xy-2446xy phospho-eIF4E(pSer209)(phospho-Eukaryotic translation initiation factor 4E)磷酸化eIF-4E（Ser209）抗原
xy-1398xy ELK1细胞转录因子ELK1抗原
xy-1756xy Elastin弹性蛋白抗原
xy-2651xy ELAVL1/HuR peptideELAVL1/HuR多肽抗原
xy-0558xy Emp1 (epithelial membrane protein 1)表皮膜蛋白1抗原
xy-1331xy sFRP-4(Secreted frizzled-related protein 4; Frizzled protein, human endometrium)抗子宫内膜抗原
xy-0547xy Endostatin内皮抑素/内皮他丁抗原
xy-0658xy E.coli O6 (Escherichia coli O6)E.coli O6大肠杆菌菌体蛋白
xy-2100xy EPEC/E.coli(enteropathogenic E．coli，EPEC)普通大肠埃希菌菌体蛋白（非致病性）
xy-1763xy EphA1 R(Ephrin A1 Receptor)EphA1-R受体抗原
xy-1424xy EPOR peptide红细胞生成素受体抗原
xy-1522xy phospho-ERK1/MAPK-1/2(pThr183 + pTyr185)磷酸化丝裂原活化蛋白激酶1/2抗原
xy-0996xy ERK(Extracellular signal-regulated kinase)丝裂原活化蛋白激酶抗原
xy-1020xy MAPK1/ERK3 (Mitogen-activated protein kinase 3; P44MAPK)丝裂原活化蛋白激酶3抗原
xy-1319xy MAPK4(Mitogen-activated protein kinase 4)丝裂原活化蛋白激酶4抗原
xy-0894xy ER- Alpha(phospho-Ser167)peptide人磷酸化雌激素受体α多肽抗原
xy-1643xy ER- Alpha(phospho-Tyr537)peptide磷酸化雌激素受体α抗原
xy-0253xy ER- Alpha /ER alpha peptide雌激素受体α抗原
xy-2098xy ER- Alpha/ER alpha peptide雌激素受体α抗原
xy-0255xy ER- Beta (Estrogen receptor-beta) peptide雌激素受体β抗原
xy-1285xy ets1/E26 (E-twenty six 1)Ets转录因子家族ets1抗原
xy-0983xy EV71(Human enterovirus 71)VP1(CT)肠道病毒71型/手足口病病毒抗原(C端)
突变型P53抗体
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文献和实验coco0663 P53 NM_000546.4 Transcript Variant: This variant (1) is a dominant transcript and encodes isoform a. 麻烦高手看下，这是野生型P53还是突变型P53？ Transcript Variant是否突变型的意思，那么NM_000546.4 所转录的是否就是突变型的P53？ 谢谢 侠骨仁医
yu_ting 现在,急需知道MDA-231是P53野生型的还是突变型的?多谢 iscience 我用“MDA-231 p53”在google里面检索了一下，初步得知该细胞株系P53突变型（The human breast cancer cell line MDA-MB-231, which has high levels of a mutant p53...）。 请参考： http://www.ncbi
【摘 要】肿瘤抑制基因——p53基因的突变可能产生p53抗体．p53抗体在肿瘤的诊断、预后及监测等方面具有重要的临床价值．目前检测p53抗体的方法，如酶联免疫分析方法，需要多个步骤，比较费时，且大部分检测指标只能是半定量，具有一定的局限性,提出了一种磁免疫电化学发光(IM-ECL)分析方法定量检测人血清p53抗体．这种新的分析方法检测人血清p53抗体的最低检测极限可达到10ng/L，标准曲线的动力学范围和线性范围达到5个数量级(0．01～1000μg／L)．我们应用IM-ECL分析法检测肺癌
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