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- 克隆性：
单克隆
- 抗体英文名：
HBsAg(H2F4)
- 抗体名：
人乙型肝炎表面抗原单克隆抗体（检测）
英文名称 HBsAg(H2F4)
中文名称 人乙型肝炎表面抗原单克隆抗体（检测）
别 名 Hepatitis B Virus Surface Antigen; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; HBSAG_HBVC5.
人乙型肝炎表面抗原单克隆抗体（检测）
说 明 书 0.1ml 0.2ml 1ml
研究领域 免疫学 细菌及病毒
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 H2F4
交叉反应 HBsAg
产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 Human Hepatitis B Surface Antigen protein
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
人乙型肝炎表面抗原单克隆抗体（检测）
产品介绍 background:
Hepatitis B Virus Surface Antigen, Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase.
Function:
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Subunit:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.
Subcellular Location:
Virion membrane.
Post-translational modifications:
Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated.
Similarity:
Belongs to the orthohepadnavirus major surface antigen family.
人乙型肝炎表面抗原单克隆抗体（检测）
xy-0058R APAF1(CT)凋亡蛋白活性因子-1抗体（C端）
xy-0059R APAF1(NT)凋亡蛋白活性因子-1抗体（N端）
xy-0662R ABCG2三磷酸腺苷结合转运蛋白G超家族成员2抗体
xy-0167R APOE载脂蛋白E抗体
xy-0112M Amyloid Precursor Protein淀粉样肽前体蛋白抗体
xy-0261R Aquaporin 2水通道蛋白-2抗体
xy-0045M AGT血管紧张素原抗体
xy-0118R Androgen receptor雄激素受体抗体
xy-2438R AVEN细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
xy-2439R Axin1轴蛋白1抗体
xy-4011R ATG9B自噬相关蛋白9B抗体
xy-4012R Apg12自噬相关蛋白12抗体
xy-3864R ATG13自噬相关蛋白13抗体
xy-4013R ATG3自噬相关蛋白3抗体
xy-4191R ADAMTS4整合素样金属蛋白酶与凝血酶4型抗体
xy-1648R phospho-ATF2 (Ser490/498)磷酸化活化复制因子2抗体
xy-1649R phospho-Amyloid Precursor Protein (Tyr757)磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体
xy-2919R ACTR丝氨酸/苏氨酸蛋白激酶ATR抗体
xy-5849R ADAM18去整合素样金属蛋白酶18抗体
xy-1634R ATF6活化转录因子6抗体
xy-1546R AP2 beta衔接蛋白β抗体
xy-1600R Gamma-Adaptin衔接蛋白γ/γ-Adaptin抗体
xy-2060R AQP9水通道蛋白-9抗体
xy-1631R Annexin A3膜粘连蛋白A3抗体
xy-1564R Annexin IV膜粘连蛋白 A4抗体
xy-12487R APG8A自噬相关蛋白8A抗体
xy-3043R phospho-Akt (Thr450)磷酸化蛋白激酶B抗体
xy-5551R phospho-AMPK alpha-1 (Thr198)磷酸化腺苷单磷酸活化蛋白激酶α1抗体
xy-2720R phospho-Akt(Thr308)磷酸化蛋白激酶B抗体
xy-15407R APOBEC3G脱氧胞苷脱氨酶蛋白抗体
xy-13637R AKAP13蛋白激酶锚定蛋白13抗体
中文名称 人乙型肝炎表面抗原单克隆抗体（检测）
别 名 Hepatitis B Virus Surface Antigen; HBsAg; HBV major surface antigen; HBV surface antigen; Hepatitis B Virus major surface antigen; Major surface antigen; S; HBSAG_HBVC5.
人乙型肝炎表面抗原单克隆抗体（检测）
说 明 书 0.1ml 0.2ml 1ml
研究领域 免疫学 细菌及病毒
抗体来源 Mouse
克隆类型 Monoclonal
克 隆 号 H2F4
交叉反应 HBsAg
产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
细胞定位 细胞膜
性 状 Lyophilized or Liquid
浓 度 1mg/1ml
免 疫 原 Human Hepatitis B Surface Antigen protein
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
人乙型肝炎表面抗原单克隆抗体（检测）
产品介绍 background:
Hepatitis B Virus Surface Antigen, Hepatitis B Virus (HBV) infection induces a disease state characterised by liver damage, inflammation and viral persistence. Infection also increases the risk of hepatocellular carcinoma. HBV belongs to the Hepadnaviridae family of viruses. Its genome consists of partially double stranded circular DNA. The DNA is enclosed in a nucleocapsid, or core antigen (HBcAg), which is surrounded by a spherical envelope (surface antigen or HBsAg). The core antigen shares its sequences with the e antigen (HBeAg) but no cross reactivity between the two proteins has been observed. The HBV genome also encodes a DNA polymerase that also acts as a reverse transcriptase.
Function:
The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assumes fusion between virion membrane and endosomal membrane (Probable). In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.
The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.
Subunit:
Li-HBsAg interacts with capsid protein and with HDV Large delta antigen. Isoform M associates with host chaperone CANX through its pre-S2 N glycan. This association may be essential for M proper secretion.
Subcellular Location:
Virion membrane.
Post-translational modifications:
Isoform M is N-terminaly acetylated at a ratio of 90%, and N-glycosylated at the pre-S2 region.
Myristoylated.
Similarity:
Belongs to the orthohepadnavirus major surface antigen family.
人乙型肝炎表面抗原单克隆抗体（检测）
xy-0058R APAF1(CT)凋亡蛋白活性因子-1抗体（C端）
xy-0059R APAF1(NT)凋亡蛋白活性因子-1抗体（N端）
xy-0662R ABCG2三磷酸腺苷结合转运蛋白G超家族成员2抗体
xy-0167R APOE载脂蛋白E抗体
xy-0112M Amyloid Precursor Protein淀粉样肽前体蛋白抗体
xy-0261R Aquaporin 2水通道蛋白-2抗体
xy-0045M AGT血管紧张素原抗体
xy-0118R Androgen receptor雄激素受体抗体
xy-2438R AVEN细胞死亡调节蛋白抗体(凋亡、半胱胺酸蛋白酶激活抑制剂)
xy-2439R Axin1轴蛋白1抗体
xy-4011R ATG9B自噬相关蛋白9B抗体
xy-4012R Apg12自噬相关蛋白12抗体
xy-3864R ATG13自噬相关蛋白13抗体
xy-4013R ATG3自噬相关蛋白3抗体
xy-4191R ADAMTS4整合素样金属蛋白酶与凝血酶4型抗体
xy-1648R phospho-ATF2 (Ser490/498)磷酸化活化复制因子2抗体
xy-1649R phospho-Amyloid Precursor Protein (Tyr757)磷酸化APP(Tyr757)淀粉样肽前体蛋白抗体
xy-2919R ACTR丝氨酸/苏氨酸蛋白激酶ATR抗体
xy-5849R ADAM18去整合素样金属蛋白酶18抗体
xy-1634R ATF6活化转录因子6抗体
xy-1546R AP2 beta衔接蛋白β抗体
xy-1600R Gamma-Adaptin衔接蛋白γ/γ-Adaptin抗体
xy-2060R AQP9水通道蛋白-9抗体
xy-1631R Annexin A3膜粘连蛋白A3抗体
xy-1564R Annexin IV膜粘连蛋白 A4抗体
xy-12487R APG8A自噬相关蛋白8A抗体
xy-3043R phospho-Akt (Thr450)磷酸化蛋白激酶B抗体
xy-5551R phospho-AMPK alpha-1 (Thr198)磷酸化腺苷单磷酸活化蛋白激酶α1抗体
xy-2720R phospho-Akt(Thr308)磷酸化蛋白激酶B抗体
xy-15407R APOBEC3G脱氧胞苷脱氨酶蛋白抗体
xy-13637R AKAP13蛋白激酶锚定蛋白13抗体
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文献和实验相关实验
荧光素标记的单克隆抗体还可用于对生物活性分子细胞内示踪。核转录因子ＮＦ －κＢ 在非转录状态 时位于胞质内，当激活时可进入细胞核，调节相关基因的转录。采用荧光标记的特异性抗体可对ＮＦ －κＢ 进行细胞内定位，从而了解细胞的状态。抑癌基因表达的ｐ５３ 蛋白与细胞周期调节及细胞凋亡有关，通常 其在细胞内的半衰期很短，常规方法难以检测。当发生突变时，则半衰期延长，引起在细胞内聚集，采用荧 光标记的特异性抗体，可检测细胞内ｐ５３ 蛋白聚集状况。 ２畅
来源： 中华医学检验杂志 作者： 曾章新 刘文星 朱忠勇 兰风华 【 摘要 】 目的 对4种胶体金免疫层析测定(GICA)试条检测乙型肝炎表面抗原(HBsAg)的性能、结果等技术参数进行评价，为各实验室的选用提供参考。方法 采用GICA法和酶免疫(EIA)法对定值的HBsAg样品和2 158份全血或血清标本同时测定，并结合有关物理现象作观察，对4种GICA试条的敏感性、特异性、试条渗透
1目的 测HBsAg主要是用于乙型肝炎的的诊断、招工体、征兵体、幼儿入学、献血员筛选、血液制品的复、了解乙肝病毒感染者的感染状况、疗效观察及预后评估，另外还用于乙型肝炎的流行病学调查。 2方法原理 采用ELISA双抗体夹心法，即酶联免疫吸附法，包被HBsA于琼脂微孔与标本中的HBsAg形成A-Ag复合物，再于酶标HBs抗体结合，加入TMB底物产生显色反应。 3性能指标 此方法快速简便、特异性强、测灵敏度度05ng/ 4标本收集 41标本类型：静脉
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人乙型肝炎表面抗原单克隆抗体（检测）
询价
