Anti-Human CD7 FITC

This 4H9 monoclonal antibody reacts with human CD7 (also known as Leu-9 or gp40),
a 40-kDa transmembrane glycoprotein belonging to the immunoglobulin superfamily.
This molecule is expressed on peripheral blood T lymphocytes and natural killer
cells, as well as on lymphoid and myeloid lineage precursors during adult hematopoiesis.
Capable of providing a costimulatory signal and associating with CD3 and CD45, CD7 is
involved in T cell activation.

CD7 has also been detected on numerous T cell-derived leukemias and lymphomias.
In fact, because CD7 expression is greater on CD4+ T cells in classical Hodgkin’s
lymphoma than in benign reactive lymph adenopathy, this molecule may be used as a
diagnostic for Hodgkin’s lymphoma.

Blocking assays demonstrate that this clone recognizes the same epitope as clone 124-1D1.