This L161 monoclonal antibody detects CD1c (also known as BDCA-1),
a glycoprotein that is noncovalently linked to beta-2 microglobulin
on thymocytes and antigen presenting cells such as dendritic and
Langerhans cells. This molecule is also expressed on some circulating
and marginal zone B cells, as well as in lymph nodes and germinal
centers. CD1c is involved in the presentation of lipid antigens such
as microbial fatty acids to effector T cells during the adaptive immune
response. Finally, alternative splicing gives rise to three different
isoforms of CD1c (soluble, membrane, and cytoplasmic/soluble isoforms).