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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保质期:
1年
- 英文名:
Granzyme B Inhibitor I-Calbiochem
- 库存:
100⁺瓶
- 供应商:
上海睿安生物13611631389
- 保存条件:
−20°C
- 规格:
1mg/瓶
Merck(Sigma)货号368050-1mg╳颗粒酶B抑制剂I上海睿安生物13611631389微信同号
一般描述:人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID50=300nM)。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID50=300nM)。
包装:1mg in Plastic ampoule
生化/生理作用
主要靶标
颗粒酶B
产物不与ATP竞争。
可逆:否
细胞可渗透性:是
靶标IC50:300nM,针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告:毒性:标准处理(A)
序列:Z-Ala-Ala-Asp-CH₂Cl
重悬:复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。
其他说明:
Gong,B.,et al.1999.Cell Growth Different.10,491.
Shi, L.,et al.1992.J. Exp.Med. 176,1521.
Odake,S.,et al.1991.Biochemistry30,2217.
法律信息:CALBIOCHEM is a registered trademark of Merck KGaA,Darmstadt,Germany



一、╳※试剂※╳:
同行评审论文
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and sub_sequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
Cell-in-cell structure mediates in-cell killing suppressed by CD44.
Yan Su et al.
Cell discovery, 8(1), 35-35 (2022-04-20)
Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke.
Ganta Vijay Chaitanya et al.
Brain pathology (Zurich, Switzerland), 21(1), 16-30 (2010-09-10)
Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of
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文献和实验Merck(Sigma)货号368050-1mg╳颗粒酶B抑制剂I上海睿安生物13611631389微信同号
一般描述:人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID50=300nM)。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID50=300nM)。
包装:1mg in Plastic ampoule
生化/生理作用
主要靶标
颗粒酶B
产物不与ATP竞争。
可逆:否
细胞可渗透性:是
靶标IC50:300nM,针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告:毒性:标准处理(A)
序列:Z-Ala-Ala-Asp-CH₂Cl
重悬:复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。
其他说明:
Gong,B.,et al.1999.Cell Growth Different.10,491.
Shi, L.,et al.1992.J. Exp.Med. 176,1521.
Odake,S.,et al.1991.Biochemistry30,2217.
法律信息:CALBIOCHEM is a registered trademark of Merck KGaA,Darmstadt,Germany



一、╳※试剂※╳:
同行评审论文
CTL-Derived Granzyme B Participates in Hippocampal Neuronal Apoptosis Induced by Cardiac Arrest and Resuscitation in Rats.
Ning-Ning Ji et al.
Frontiers in neurology, 10, 1306-1306 (2020-01-11)
Hippocampal neuronal apoptosis is a devastating consequence of cardiac arrest (CA) and sub_sequent cardiopulmonary resuscitation (CPR). In this study, we assessed the contribution of cytotoxic T lymphocyte (CTL)-derived toxic mediator granzyme B (Gra-b) to the hippocampal neuronal apoptosis following CA/CPR
Cell-in-cell structure mediates in-cell killing suppressed by CD44.
Yan Su et al.
Cell discovery, 8(1), 35-35 (2022-04-20)
Penetration of immune cells into tumor cells was believed to be immune-suppressive via cell-in-cell (CIC) mediated death of the internalized immune cells. We unexpectedly found that CIC formation largely led to the death of the host tumor cells, but not
Role of cytotoxic protease granzyme-b in neuronal degeneration during human stroke.
Ganta Vijay Chaitanya et al.
Brain pathology (Zurich, Switzerland), 21(1), 16-30 (2010-09-10)
Infiltration of leukocytes into post-ischemic cerebrum is a well-described phenomenon in stroke injury. Because CD-8(+) T-lymphocytes secrete cytotoxic proteases, including granzyme-b (Gra-b) that exacerbates post-ischemic brain damage, we investigated roles of Gra-b in human stroke. To study the role of
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