Merck(Sigma)货号368050-1mg╳颗粒酶B抑制剂I询订13611631389微信同号
一般描述:人和鼠丝氨酸蛋白酶颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID50=300nM)。
人和鼠颗粒酶B的弱抑制剂。还通过片段化蛋白2(一种与颗粒酶B同源的大鼠淋巴细胞颗粒蛋白酶)抑制淋巴细胞中与凋亡相关的DNA片段化(ID
50=300nM)。
包装:1mg in Plastic ampoule
生化/生理作用
主要靶标
颗粒酶B
产物不与ATP竞争。
可逆:否
细胞可渗透性:是
靶标IC
50:300nM,针对片段化蛋白2引起的淋巴细胞凋亡相关DNA片段化
警告:毒性:标准处理(A)
序列:Z-Ala-Ala-Asp-CH₂Cl
重悬:复溶后,等分并冷冻保存(-20°C)。储备溶液在-20°C下可稳定保存至多3个月。
其他说明:
Gong,B.,et al.1999.
Cell Growth Different.10,491.
Shi, L.,et al.1992.
J. Exp.Med. 176,1521.
Odake,S.,et al.1991.
Biochemistry30,2217.
法律信息:CALBIOCHEM is a registered trademark of Merck KGaA,Darmstadt,Germany
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