Uprosertib优普色替,1047634-65-0

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Uprosertib

CAS No. : 1047634-65-0

MCE 国际站：Uprosertib

产品活性：Uprosertib (GSK2141795) 是一种有效的，选择性的 Akt 广谱抑制剂，抑制 Akt1/Akt2/Akt3 的活性，IC₅₀ 值分别为 180/328/38 nM。

研究领域：PI3K/Akt/mTOR

作用靶点：Akt

In Vitro: Uprosertib (GSK2141795) inhibits Akt1/2/3 with the K_d values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib (GSK2141795) in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding.

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