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- HY-B0249
- 2025年12月05日
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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
2',3'-Dideoxyinosine; ddI
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
69655-05-6
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥567.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥291.0 |
| 规格： | 10 mg | 产品价格： | ￥515.0 |
| 规格： | 50 mg | 产品价格： | ￥980.0 |
| 规格： | 100 mg | 产品价格： | ￥1372.0 |
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Didanosine
CAS No. : 69655-05-6
MCE 国际站：Didanosine
产品活性：Didanosine (2',3'-Dideoxyinosine; ddI) 是一种有效且具有口服活性的双脱氧核苷类似物，也是一种有效的核苷逆转录酶 (nucleoside reverse transcriptase) 抑制剂。Didanosine 对 HIV 显示出抗逆转录病毒活性。
研究领域：Anti-infection
作用靶点：HIV | Reverse Transcriptase
In Vitro: Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours.
Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection.
Didanosine (5, 10, 50, 100 ug/ml; 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells.
In Vivo: Didanosine (100, 150 mg/kg; p.o.; daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse.
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