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- 详细信息
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
SC 69124
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
198470-84-7
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥660.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥600.0 |
| 规格： | 50 mg | 产品价格： | ￥900.0 |
| 规格： | 100 mg | 产品价格： | ￥1500.0 |
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Parecoxib
CAS No. : 198470-84-7
MCE 国际站：Parecoxib
产品活性：Parecoxib (SC 69124) 是一种选择性强、口服活性强的 COX-2 抑制剂，Valdecoxib (HY-15762) 的前体。Parecoxib Sodium 是一种非甾体抗炎试剂 (NSAID)，可抑制前列腺素(PG) 的合成。动物实验中，Parecoxib Sodium 可用于缓解术后急性疼痛和骨关节炎、类风湿关节炎等慢性炎症症状。
作用靶点：COX
In Vitro: Parecoxib (0-200 μM; 24-48 hours) inhibits the cell proliferation of GBM cells in a dose-dependent manner in GBM cells.
Parecoxib (200 μM; 24-48 hours) results in a decreasee migratory ability of U343 cells than PBS-treated group.
In Vivo: Parecoxib (intraperitoneal injection; 2.5, 5.0 or 10 mg/kg; once a day; 21 days) does not affect locomotor activity in the elevated plus-maze test, and Parecoxib at 5 and 10 mg/kg shows higher levels of percentage of time spent in the open arms.
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