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- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
P071
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
83881-52-1
- 规格：
10 mM * 1 mL/100 mg/200 mg/500 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥550.0 |
|---|---|---|---|
| 规格： | 100 mg | 产品价格： | ￥500.0 |
| 规格： | 200 mg | 产品价格： | ￥810.0 |
| 规格： | 500 mg | 产品价格： | ￥1150.0 |
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Cetirizine dihydrochloride
CAS No. : 83881-52-1
MCE 国际站：Cetirizine dihydrochloride
产品活性：Cetirizine dihydrochloride 是羟嗪的羧化代谢物，是第二代抗组胺药。Cetirizine dihydrochloride 是一种特异的、口服有效的、H1 受体 的长效拮抗剂。Cetirizine dihydrochloride 标记抗过敏特性，抑制过敏反应期间嗜酸性粒细胞趋化。
研究领域：GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation
作用靶点：Histamine Receptor
In Vitro: Cetirizine (>5 μM) at higher concentrations can reduce the release of GM-CSF and IL-8 from A549 cells stimulated with IL-1β. Cetirizine exerts anti-inflammatory effects beyond histamine H1-receptor antagonist[2].
In Vivo: Cetirizine (20 mg/kg, mice, orally) exerts its anti-inflammatory effects by inhibiting MIF as well as IL-8 production in mice immunized and challenged with ragweed pollen[3].
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文献和实验佚名 仙特敏(zyrtec)有效成份为盐酸西替利嗪(Cetirizine hydrochloride)，是一种新一代长效、高效H1受体拮抗剂。其作用机理独特，不仅对抗外周H1受体而阻断组胺作用，还直接对抗组胺以及降低变态反应部位组胺浓度。有效的抑制炎症细胞(嗜酸粒细胞和嗜中性粒细胞)的趋化和活化。近年来广泛应用于临床治疗各种变态反应性疾病，我院在近几年应用的过程中
Overview of Experimental Models of the Blood‐Brain Barrier in CNS Drug Discovery
functionality and transport machineries of human ECV304 cells. Med. Sci. Monitor 16:BR52‐BR60. Bartholomäus, I., Kawakami, N., Odoardi, F., Schläger, C., Miljkovic, D., Ellwart, J.W
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