Aldoxorubicin,1361644-26-9

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Aldoxorubicin

CAS No. : 1361644-26-9

MCE 国际站：Aldoxorubicin

产品活性：Aldoxorubicin (INNO-206) 是多柔比星 (DNA 拓扑异构酶 II 抑制剂) 的白蛋白结合前体，在酸性条件下从白蛋白中释放出来。 Aldoxorubicin (INNO-206) 在各种癌细胞系和小鼠肿瘤模型中具有有效的抗肿瘤活性。

研究领域：Cell Cycle/DNA Damage  |  Antibody-drug Conjugate/ADC Related

作用靶点：Topoisomerase  |  ADC Cytotoxin

In Vitro: Aldoxorubicin (INNO-206)? (0.27 to 2.16 μM) inhibits blood vessel formation and reduces multiple myeloma cell growth in a pH-dependent fashion.

In Vivo: Aldoxorubicin (INNO-206) (10.8 mg/kg, i.v.) shows significantly smaller tumor volumes and IgG levels on days 28, and is well tolerated with 90% of mice surviving until the termination of the study in the mice bearing the LAGκ-1A tumor. Aldoxorubicin (INNO-206) shows a good safety profile at doses up to 260 mg/mL doxorubicin equivalents, and is able to induce tumor regressions in breast cancer, small cell lung cancer and sarcoma in phase I study. Aldoxorubicin (INNO-206) shows superior activity over doxorubicin in a murine renal cell carcinoma model and in breast carcinoma xenograft models.

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