R121919,195055-66-4

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R121919 hydrochloride

CAS No. : 195055-66-4

MCE 国际站：R121919 hydrochloride

产品活性：R121919 (NBI30775) hydrochloride 是一种高效的，选择性的 CRF1R 拮抗剂，K_i 值为 2 至 5 nM。R121919 hydrochloride 具有抗抑郁和抗焦虑作用。R121919 hydrochloride 可缓解大鼠的防御性戒断。

研究领域：GPCR/G Protein

作用靶点：CRFR

In Vitro: R121919 hydrochloride is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types.

In Vivo: R121919 (NBI30775) hydrochloride dose dependently decreases adrenocorticopin hormone and Corticosterone (HY-B1618) responses to restraint stress in rats. Peak plasma adrenocorticopin hormone and corticosterone concentrations at a dose of 10 mg/kg R121919 are 9 and 25%, respectively.
R121919 hydrochloride reduces levels of anxiety in mice with a steep dose-response curve.

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