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- 2025年06月19日
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- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
132836-42-1
- 规格：
10 mM * 1 mL/10 mg/50 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1351.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1228.0 |
| 规格： | 50 mg | 产品价格： | ￥4315.0 |
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YS-49
CAS No. : 132836-42-1
产品活性：YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors.
研究领域：PI3K/Akt/mTOR | GPCR/G Protein | Neuronal Signaling
作用靶点：Akt | PI3K | Angiotensin Receptor | Adrenergic Receptor
In Vitro: YS-49 (1-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) concentration-dependently inhibits the accumulation of nitrite in both RAVSMC and RAW 264.7 exposed to lipopolysaccharide (LPS) plus INF-γ, with IC50 values of 22 μM and 30 μM, respectively.
YS-49 (10-100 μM; 18 hours; RAVSMC and RAW 264.7 cells) suppresses iNOS gene expression induced by LPS and/or cytokines in RAVSMC and RAW 264.7 cells at the transcriptional level.
In Vivo: YS-49 (5 mg/kg; intraperitoneal injection; 8 hours; male Sprague Dawley rats) treatment significantly reduces serum NOx levels in LPS-treated rats, the NOx levels reduce from 86 μM to 34 μM.
相关产品：Endocrinology Compound Library | Reprogramming Compound Library | Natural Product Like Compound Library | Kinase Inhibitor Library | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | PI3K/Akt/mTOR Compound Library | Bioactive Compound Library Plus | 3-Methyladenine | LY294002 | MK-2206 dihydrochloride | Angiotensin II human | Wortmannin | Alpelisib | Isoprenaline hydrochloride | SC79 | Copanlisib | Buparlisib | Quercetin | Idelalisib | Honokiol | ICI 118,551 hydrochloride | Capivasertib | Norepinephrine bitartrate monohydrate | 740 Y-P | Dactolisib | IPI549 | Pictilisib | Losartan | Propranolol hydrochloride | (R)-(-)-Phenylephrine hydrochloride | Ipatasertib | AKT inhibitor VIII | SAR405 | LY3023414 | Duvelisib | Fimepinostat | GSK-690693
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