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YK-4-279
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Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
货期:1-2天
MedChemExpress LLC
1037184-44-3
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1037184-44-3
MCE 国际站:YK-4-279
产品活性:YK-4-279 能够阻断 RNA 解旋酶 A (RHA) 与 EWS-FLI1 (致癌蛋白) 的结合。YK-4-279 诱导细胞凋亡并且对多种癌细胞具有抗增殖活性。YK-4-279 有一个手性中心并且可以被分离成两个对映体。YK-4-279 可用于癌症的研究。
研究领域:Cell Cycle/DNA Damage | Apoptosis
作用靶点:DNA/RNA Synthesis | Apoptosis
In Vitro: YK-4-279 (3-30 μM; overight) dissociates EWS-FLI1 from RHA in Ewing’s sarcoma family tumor (ESFT) cells.?YK-4-279 (3-30 μM; 14 h) nearly eliminates cyclin D1 in TC32 cells.?YK-4-279 (3-30 μM; 72 h) potently and specifically inhibits ESFTs.?YK-4-279 (50 μM; 6 h) induces substantial apoptosis of ESFT cells.?YK-4-279 (0.1-30 μM; 72 h) inhibits the growth of ESFT, prostate, breast and pancreatic cancer cells.
In Vivo: YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth.
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