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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, stored under nitrogen
- 英文名：
GS 4071; Ro 64-0802; Oseltamivir carboxylate
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
187227-45-8
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥715.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥285.0 |
| 规格： | 5 mg | 产品价格： | ￥650.0 |
| 规格： | 10 mg | 产品价格： | ￥1100.0 |
| 规格： | 25 mg | 产品价格： | ￥2310.0 |
| 规格： | 50 mg | 产品价格： | ￥3465.0 |
| 规格： | 100 mg | 产品价格： | ￥4950.0 |
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Oseltamivir acid
CAS No. : 187227-45-8
MCE 国际站：Oseltamivir acid
产品活性：Oseltamivir acid (GS 4071)，Oseltamivir phosphate 的活性代谢产物, 是流感病毒神经氨酸酶 (IC50=2 nM) 的口服生物有效的，选择性的抑制剂，对流感病毒 A 和 B 都有活性。
研究领域：Anti-infection | Metabolic Enzyme/Protease
作用靶点：Influenza Virus | Drug Metabolite
In Vitro: Oseltamivir acid inhibits virus replication in vitro and in vivo. Influenza B and A/H1N1 viruses appeare to be sensitive to Oseltamivir (mean B IC50 value: 13 nM; mean H1N1 IC50 value: 1.34 nM), while A/H1N2 and A/H3N2 viruses are more sensitive to Oseltamivir (mean H3N2 IC50 value: 0.67 nM; mean H1N2 IC50 value: 0.9 nM).
?In neuraminidases inhibition assays with influenza A viruses, the IC50 of RWJ-270201 (approximately 0.34 nM) is comparable to that of Oseltamivir carboxylate (0.45 nM) For influenza B virus isolates, the IC50 of RWJ-270201 (1.36 nM) is comparable to that of Zanamivir (2.7 nM) and less than that of Oseltamivir carboxylate (8.5 nM).
In Vivo: Oseltamivir acid (0.1, 1, or 10 mg/kg/day, twice daily by oral gavage) produces a dose-dependent antiviral effect against Vietnam/1203/04 (VN1203/04) virus. The 5-day regimen at 10 mg/kg/day protects 50% of mice; deaths in this treatment group are delayed and indicated the replication of residual virus after the completion of treatment. Dosages of 1 and 10 mg/kg/day significantly reduced virus titers in organs and provided 60% and 80% survival rates, respectively.
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文献和实验值为：7.35-7.45；PaCO2正常值为：35-45；HCO3- 正常值为：22-26. 也要记住下图1，需注意的是，此方法中PaCO2是反的。Acidic：酸；Neutral：正常；Basic：碱 图1 Step 2、确定pH是酸中毒还是碱中毒 通过pH值确定酸中毒或碱中毒。健康成人的pH水平在7.35-7.45。人体努力保持pH平衡。 pH pH > 7.45
Accelerated Molecular Dynamics in Computational Drug Design
emphasis is placed on the use of these methods in computer-aided drug design, and the example of oseltamivir binding to neuraminidase is highlighted for both cases.
probe amplification，MS-MLPA) Anders O.H.等2005年改进MLPA[44]为MS-MLPA[45]用于检测特异位点的甲基化。MS-MLPA中，针对甲基化的和非甲基化的位点分别设计两个探针，每个探针都包括两个寡核苷酸部分，其中短的部分由合成产生，长的部分来源于phageM13的衍生物，后者有一个非杂交填充片段，不同探针其长度不同。探针的两个寡核苷酸杂交序列均与目标序列互补，其末端都连有相同的PCR引物。且要求[45]设计的MS-MLPA的探针要有甲基化敏感的限制性内切
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