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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
NVP-AEE 788
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
497839-62-0
- 规格：
10 mM * 1 mL/5 mg/10 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥880.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥800.0 |
| 规格： | 10 mg | 产品价格： | ￥1300.0 |
| 规格： | 50 mg | 产品价格： | ￥4200.0 |
| 规格： | 100 mg | 产品价格： | ￥6700.0 |
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AEE788
CAS No. : 497839-62-0
MCE 国际站：AEE788
产品活性：AEE788是EGFR和ErbB2的抑制剂，IC50值分别为2和6 nM。
研究领域：JAK/STAT Signaling | Protein Tyrosine Kinase/RTK | Apoptosis
In Vitro: AEE788 inhibits EGFR and VEGF receptor tyrosine kinases in the nM range (IC50:EGFR 2 nm, ErbB2 6 nm, KDR 77 nm, and Flt-1 59 nm). In cells, growth factor-induced EGFR and ErbB2 phosphorylation is also efficiently inhibited (IC50:11 and 220 nm, respectively). AEE788 demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines (including EGFRvIII-dependent lines) and inhibits the proliferation of epidermal growth factor- and VEGF-stimulated human umbilical vein endothelial cells. Treatment of cutaneous SCC cells with AEE788 leads to dose-dependent inhibition of EGFR and VEGFR-2 phosphorylation, growth inhibition, and induction of apoptosis.
In Vivo: AEE788 efficiently inhibits growth factor-induced EGFR and ErbB2 phosphorylation in tumors for >72 h. AEE788 also inhibits VEGF-induced angiogenesis in a murine implant model. In mice treated with AEE788, tumor growth is inhibited by 54% at 21 days after the start of treatment compared with control mice.
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