IC BlockTM Protein Transport I

Structure-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein

, and the unexpected location of the inhibitor-binding site suggests a transport mechanism for arachidonic acid and provides functional insights into leukotriene biosynthesis. This chapter describes how this human integral membrane crystal structure was solved

High-Throughput Automated Confocal Microscopy Imaging Screen of a Kinase-Focused Library to Identify p38 Mitogen-Activated Protein Kinase Inhibitors U

exhibited IC50 s less than 1 μM, and at least one novel structural class of p38 inhibitor was identified using this HCA/HCS chemical biology screening approach.

Evaluating Modulators of “Regulator of G‐protein Signaling” (RGS) Proteins

of an IC50 for RGS protein inhibition. View Image   Figure 2.8.5 RGS4 is allosterically modulated