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- T-Cell & B-Cell Activation DNA Methylation PCR Array
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- 2026年02月03日
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- 详细信息
- 文献和实验
- 技术资料
- 服务名称：
T-Cell & B-Cell Activation DNA Methylation PCR Array
- 提供商：
SAB
| Human T-Cell & B-Cell Activation DNA Methylation PCR Array: EAHS-531Z | ||||||||||||||||||
| The Human T-Cell and B-Cell Activation EpiTect Methyl II Signature PCR Array profiles the promoter methylation status of a panel of 22 genes whose involvement in T and B lymphocyte biology has been well documented. Profiling cellular or fresh tissue DNA samples with these arrays may help correlate CpG island methylation status with the resident T cells' relative capacity for activation by external stimuli from immune and inflammatory response pathways. The results may also help provide insights into the molecular mechanisms and biological pathways behind diseases involving T cell biology such as asthma, allergies, autoimmune disorders, leukemia, and lymphoma. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the promoter methylation status of 22 different genes regulating T cell and B cell biology with this DNA methylation PCR array. Both 96-well and 384-well ( 4 X 96 ) formats are available.
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T Cell Proliferation Genes: BLM, CD274, CD276, CD47, FOXP3, ICOSLG, IL12A, IL7, NCK1, RIPK2, TGFB1.
Cell Adhesion & Migration Regulators: ADA, CD47, DPP4, IL12A, NCK1, TGFB1.
MHC Protein Complex Associated Proteins: CD8A, LAG3, MICB.
Cell Cycle Regulators: BLM, IL12A, TGFB1.
Other T Cell Activation Regulators: CD7, MAP3K7, THY1.
B Cell Activation: ADA, ICOSLG, IL7, TGFB1.
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文献和实验strands [J]. Proc Natl Acad Sci USA, 1992, 89: 1827–1831.[26]朱燕. DNA的甲基化的分析与状态检测 [J]. 现代预防医学, 2005, 32(9): 1070-1073.[27]沈佳尧, 侯鹏, 祭美菊等. DNA甲基化方法研究现状 [J]. 生命的化学, 2003, 23(2): 149-151.[28]Herman J G, Graff J R, Myohanen S, et al. Methylation-specific PCR
Clonality - X Chromosome Inactivation Assay
of the resuspended DNA into a reaction tube. Add 1 µl REact buffer 2. Add 1 µl Hha I. Incubate overnight at 37°C. Incubate at 90°C for 10 min. Use 2 µl of this digested DNA for PCR (see below). Use 2 µl of the non-digested DNA from B18 above as a negative
Clinical Applications of BAC Array-CGH to the Study of Diffuse Large B-Cell Lymphomas
BAC array-CGH is a powerful method to identify DNA copy number changes (gains, amplifications and deletions) on a genome-wide scale, and to map these changes to genomic sequence. It is based on the analysis of genomic DNA isolated from test
