α-conotoxin PeIA

α-conotoxin PeIA
Discriminates between α9α10 and α7 nAChRs

α-conotoxin PeIA has been isolated from the venom of Conus pergrandis. α-conotoxin PeIA discriminates between α9α10 and α7 nicotinic acetylcholine receptors (AChRs) with IC₅₀ values of 7-50 nM (depending of the authors) and 1.8 µM, respectively. The toxin is also known to block α3β2 nicotinic AChRs (with an IC₅₀ of 97 nM) and block voltage-gated N-type Ca²⁺ channels in rat DRG neurons with an IC₅₀ of 1.1 nM. No significant inhibition of ACh-evoked currents for nicotinic α4β2 and muscle αβγδ AChRs by 1 µM α-conotoxin PeIA was observed. The action of α-conotoxin PeIA is fully reversible after washout of the peptide in the extracellular medium.

α-conotoxin PeIA technical information

AA sequence: Gly-Cys²-Cys³-Ser-His-Pro-Ala-Cys⁸-Ser-Val-Asn-His-Pro-Glu-Leu-Cys¹⁶-NH₂
Disulfide bonds: Cys²-Cys⁸, Cys³-Cys¹⁶
Length (aa): 16
Formula: C₆₅H₉₈N₂₂O₂₁S₄
Molecular Weight: 1651.9 Da
Appearance: White lyophilized solid
Solubility: water or saline buffer
CAS number: not available
Source: Synthetic
Purity rate: > 99 %

13CON017-00100	α-conotoxin PeIA	0.1mg
13CON017-50100	α-conotoxin PeIA	5 x 0.01mg
13CON017-00500	α-conotoxin PeIA	0.5mg