ProTx-II

ProTx-II
Na_v1.7 selective inhibitor

ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels.ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-IIblocks Na_v1.7 with an IC₅₀ value of around 300 pM, Na_v1.2, Na_v1.5 and Na_v1.6 with IC₅₀ values of 41 nM, 79 nM and 26 nM respectively. It also acts on Ca_v3.1/CACNA1G and interacts more weakly with the related T-Type channel Ca_v3.2/CACNA1H but potently inhibits the L-type calcium channel Ca_v1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors.

ProTx-II technical information

AA sequence: Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Ser-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Met-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Leu-Trp-OH
Disulfide bonds: Cys²-Cys¹⁶, Cys⁹-Cys²¹ and Cys¹⁵-Cys²⁵
Length (aa): 30
Formula: C₁₆₈H₂₅₀N₄₆O₄₁S₈
Molecular Weight: 3828.00 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 484598-36-9
Source: Synthetic
Purity rate: > 95 %

07PTX002-00100	ProTx-II	0.1mg
07PTX002-00500	ProTx-II	0.5mg
07PTX002-01000	ProTx-II	1mg