ADWX-1

ADWX-1
K_v1.3 channel blocker

ADWX-1 is an optimised synthetic analog of the scorpion peptide BmKTx. ADWX-1 is known to block voltage-gated mK_v1.3 channel with a high affinity (IC₅₀ = 1.89 pM) and selectivity (340 fold greater affinity than for voltage-dependent ).ADWX-1 inhibits CD4⁺ CCR7^- T-cell proliferation. ADWX-1 is an interesting therapeutic candidate to treat auto-immune disorders such as multiple sclerosis, type-1 diabetes, rheumatoid arthritis and psoriasis. This peptide is a valuable tool for studying the structure-function of K_v1.3 channel and auto-immunity pathways.

Product Specifications

AA sequence: Val-Gly-Ile-Asn-Val-Lys-Cys⁷-Lys-His-Ser-Arg-Gln-Cys¹³-Leu-Lys-Pro-Cys¹⁷-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁷-Thr-Asn-Gly-Lys-Cys³²-His-Cys³⁴-Thr-Pro-Lys-OH
Disulfide bonds between: Cys⁷-Cys²⁷, Cys¹³-Cys³², Cys¹⁷-Cys³⁴
Length (aa): 37
Formula: C₁₆₉H₂₈₁N₅₇O₄₆S₇
Molecular Weight: 4071.90 Da
Purity rate: > 98%
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: not available
Source: Synthetic

13ADW001-00100	ADWX-1	0.1mg
13ADW001-00500	ADWX-1	0.5mg
13ADW001-01000	ADWX-1	1mg