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- Smartox Biotechnology
- 08CON002
- 2025年12月10日
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Catalog N : 08CON002
ω-Conotoxin MVIIC / Omega conotoxin MVIIC
Blocker of P/Q and N-type Ca2+ channels
| ω-conotoxin MVIIC (omega conotoxin MVIIC) has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. It inhibits presynaptic Ca2+ channels, including the Ca2+ channels responsible for Ca2+ uptake by rat brain synaptosomes, the P-type Ca2+ channels in cerebellar Purkinje cells, and a significant fraction of ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats. |
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ω-conotoxin MVIIC technical information
AA sequence: Cys1-Lys-Gly-Lys-Gly-Ala-Pro-Cys8-Arg-Lys-Thr-Met-Tyr-Asp-Cys15-Cys16-Ser-Gly-Ser-Cys20-Gly-Arg-Arg-Gly-Lys-Cys26-NH2
Disulfide bonds: Cys1-Cys16, Cys8-Cys20 and Cys15-Cys26
Length (aa): 26
Formula: C106H178N40O32S7
Molecular Weight: 2750.20 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: [147794-23-8]
Source: Synthetic
Purity rate: > 97 %
| 08CON002-00100 | ω-conotoxin MVIIC | 0.1mg |
| 08CON002-00500 | ω-conotoxin MVIIC | 0.5mg |
| 08CON002-01000 | ω-conotoxin MVIIC | 1mg |
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文献和实验Characterization of Calcium Channel Binding
Membranes Basic Protocol 2: Measurement of [3H]PN200‐100 Displacement Binding to L‐type Calcium Channels in Cardiac Membranes Basic Protocol 3: Measurement of [125I]ω‐Conotoxin‐MVIIA Saturation Binding to N‐type
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