Kaliotoxin-1

Kaliotoxin-1

Kaliotoxin-1 (KTX1) has been isolated from the venom of the Scorpion Androctonus mauretanicus mauretanicus. Kaliotoxin-1 shows a high structural affinity with Iberiotoxin and Charybdotoxinthat inhibit KCa2+ channels activity. According to several studies, it appears that Kaliotoxin-1 has a weak inhibitory effect on KCa2+ channels, but it is a potent and selective inhibitor of voltage-activated potassium channel (Kv1.1, Kv1.2, Kv1.3).

Kaliotoxin-1 technical information

AA sequence: Gly-Val-Glu-Ile-Asn-Val-Lys-Cys⁸-Ser-Gly-Ser-Pro-Gln-Cys¹⁴-Leu-Lys-Pro-Cys¹⁸-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁸-Met-Asn-Arg-Lys-Cys³³-His-Cys³⁵-Thr-Pro-Lys-OH
(Disulfide bonds between Cys⁸-Cys²⁸, Cys¹⁴-Cys³³ and Cys¹⁸-Cys³⁵)
Length (aa): 38
Formula: C₁₇₁H₂₈₃N₅₅O₄₉S₆
Molecular Weight: 4149.89 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 97 %

08KTX002-00100	Kaliotoxin-1	0.1mg
08KTX002-00500	Kaliotoxin-1	0.5mg
08KTX002-01000	Kaliotoxin-1	1mg