Iberiotoxin

Iberiotoxin
Blocker of high conductance Ca²⁺-activated K⁺ channel

Iberiotoxin (IbTx) is a toxin that was originally isolated from Buthus tamulus scorpion venom. Iberiotoxin inhibits selectively the high conductance Ca²⁺-activated K⁺ channel (K_Ca1.1) at nanomolar concentrations (IC₅₀ ~2 nM). This toxin does not affect other types of calcium-dependent or voltage-dependent K⁺ channels. Iberiotoxin is a valuable tool to study specifically Maxi-K channels.

Iberiotoxin technical information

AA sequence: pGlu-Phe-Thr-AspVal-Asp-Cys-Ser-Val-Ser-Lys-GIu-Cys-Trp-Ser-Val-Cys-Lys-Asp-Leu-Phe-Gly-Val-Asp-Arg-Gly-Lys-Cys-Met-Gly-Lys-Lys-Cys-Arg-Cys-Tyr-GIn-OH
Disulfide bridges: Cys⁷-Cys²⁸, Cys¹³-Cys³³, Cys¹⁷-Cys³⁵
Length (aa): 37
Formula: C₁₇₉H₂₇₄N₅₀O₅₅S₇
Molecular Weight: 4230.8 Da
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number: 129203-60-7
Source: Synthetic
Purity rate: > 95 %

12IBX001-50010	Iberiotoxin	5x 0.01mg
12IBX001-00100	Iberiotoxin	0.1mg
12IBX001-00500	Iberiotoxin	0.5mg
12IBX001-01000	Iberiotoxin	1mg