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- Sino Biological
- 70026-D08B
- 2025年08月12日
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50 µg
蛋白名称：EGFR蛋白, EGFR protein
蛋白构建：A DNA sequence encoding the canine EGFR (XP_533073.3) (Met1-Ser618) was expressed with a C-terminal polyhistidine tag.
表达宿主：Baculovirus-Insect Cells
蛋白纯度：> 90 % as determined by SDS-PAGE
蛋白活性：Measured by its binding ability in a functional ELISA. Immobilized canine EGFR-His at 10 μg/ml (100 μl/well) can bind biotinylated canine His-EGF(Cat:70013-D07E), The EC50 of biotinylated canine His-EGF(Cat:70013-D07E) is 0.16-0.36μg/ml
蛋白内毒素：< 1.0 EU per μg of the protein as determined by the LAL method
预测N端：Met
蛋白分子量：The recombinant canine EGFR comprises 629 amino acids and has a predicted molecular mass of 69.8 kDa. The apparent molecular mass of the protein is approximately 87.2 kDa in SDS-PAGE under reducing conditions.
蛋白NP号：XP_533073.3
蛋白氨基酸序列：Met1-Ser618
蛋白标签：C-His
蛋白保存条件：Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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文献和实验受体阳性的乳腺癌细胞有较小程度的细胞毒性，这种情况与在异种移植小鼠模型中的表现一致。体外实验中，在 TNBC 细胞的诱导下，初始 EGFR CAR-T 迅速扩增，同时还会激活 interferomγ, granzyme-perforin-PARP 和 FaS-FADD-caspase 等相关信号通路。 实验团队首先通过免疫印迹和流式细胞术的方法验证 EGFR 高表达于三阴乳腺癌。其中免疫印迹（immunoblotting）又称蛋白质印迹（Western blotting），是根据抗原抗体的特异性结合检测
Clinical Advancement of EGFR Inhibitors in Cancer Therapy
The epidermal growth factor receptor (EGFR) represents one of the most promising molecular targets in cancer therapeutics. An array of EGFR inhibitory drugs have been developed that are progressing rapidly in oncology clinical trials
Phosphotyrosine Kinase Assays as a Prescreen for Inhibitors of EGFr
The epidermal growth factor receptor (EGFr) is a 170-kDa glycosylated transmembrane protein found in a wide variety of tissues (1 ). It is the receptor for epidermal growth factor (EGF), transforming growth factor α (TGFα), and other related
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