Oligomycin Complex

Oligomycin Complex 货号11341，规格1mg，5mg，10mg  如需购买Cayman产品，或咨询产品技术问题，请联系Cayman代理商欣博盛生物。

Product Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F₁F_O ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis.¹ Oligomycin complex is a mixture of oligomycins A (Item No. 11342), B (Item No. 11343), and C. Oligomycin A is a selective inhibitor of mitochondrial F₁F_O-ATP synthase that induces apoptosis in a variety of cell types (average GI₅₀ = 270 nM).^2,3,4 Oligomycin B is a nonselective inhibitor of ATP synthases. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.^1,5

WARNING This product is not for human or veterinary use.
 

Product Description References

1. Grover, G.J., and Malm, J. Pharmacological profile of the selective mitochondrial F1F0 ATP hydrolase inhibitor BMS-199264 in myocardial ischemia. Cardiovasc.Ther. 26, 287-296 (2008).

2. Salomon, A.R., Voehringer, D.W., Herzenberg, L.A., et al. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem. Biol. 8, 71-80 (2001).

3. Shin, Y.K., Yoo, B.C., Chang, H.J., et al. Down-regulation of mitochondrial F1F0-ATP synthase in human colon cancer cells with induced 5-fluorouracil resistance. Cancer Res. 65(8), 3162-3170 (2005).

4. Laatsch, H., Kellner, M., Wolf, G., et al. Oligomycin F, a new immunosuppressive homologue of oligomycin A. J. Antibiot. (Tokyo) 46(9), 1334-1341 (1993).

5. Jackson, J.G., and Thayer, S.A. Mitochondrial modulation of Ca²⁺-induced Ca²⁺-release in rat sensory neurons. J. Neurophysiol. 96, 1093-1104 (2006).