- 询价
- Biotium
- 美国
- 70014
- 2025年09月12日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C避光
- 英文名：
JC-1 (IODIDE SALT) 70014
- 库存：
99
- 供应商：
Biotium
- CAS号：
47729-63-5
JC-1 (5,5′,6,6′-Tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine, iodide) is a mitochondrial dye that stains mitochondria in living cells in a membrane potential-dependent fashion. JC-1monomer is in equilibrium with so-called J-aggregates, which are favored at higher dye concentration or higher mitochondrial membrane potential. The monomer JC-1 has green fluorescence (λ Em = 527 nm), while the J-aggregates have red fluorescence (λ Em = 590 nm). Therefore, it is possible to use fluorescence ratioing technique to study mitochondrial membrane potentials. JC-1 is particularly useful for apoptosis studies. In apoptotic cells, the dye stays in the cytoplasm and fluoresces green. It has also been used in high throughput drug screening applications.
Biotium offers JC-1 as either iodide salt or chloride salt (#70011). Both forms have identical spectral properties. The iodide salt is the more commonly used form, however some researchers may prefer the chloride salt because chloride is the most prevalent anion in biological systems.
- ε (MeOH) = 190,000
- Red solid soluble in DMSO
- Store at 4°C and protect from light, especially in solution
- C25H27Cl4IN4
- MW: 652
- [47729-63-5]
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文献和实验线粒体荧光探针大全：TMRM，Mitotracker，JC-1
-fluorescent JC-1 probe (5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolylcarbocyanine iodide, T3168; Figure 22.13) exists as a monomer at low concentrations or at low membrane potential. However, at higher concentrations (aqueous solutions above 0.1 µM
线粒体跨膜电位DYmt的下降，被认为是细胞凋亡级联反应过程中最早发生的事件，它发生在细胞核凋亡特征（染色质浓缩、DNA断裂）出现之前，一旦线粒体DYmt崩溃，则细胞凋亡不可逆转。 线粒体跨膜电位的存在，使一些亲脂性阳离子荧光染料如Rhodamine 123、3，3-Dihexyloxacarbocyanine iodide[DiOC6（3）]、Tetrechloro-tetraethylbenzimidazol carbocyanine iodide[JC-1]、Tetramethyl
Flow Cytometric Methods for Sperm Assessment
) for assessing sperm viability; the double stain PNA-FITC (peanut agglutinin-fluorescein isothiocyanate) and PI for assessing acrosomal integrity combined with sperm viability; and JC-1 (5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethyl-benzimidazolylcarbocyanine iodide
