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- 详细信息
- 技术资料
- 保质期：
2 years
- 英文名：
Wnt-C59
- 库存：
10
- 供应商：
上海伟进生物科技有限公司
- CAS号：
1243243-89-1
- 保存条件：
-20℃
- 规格：
2mg
Biological Activity
Wnt-C59 was first disclosed in patent WO2010101849 as a potent Wnt signaling modulator with IC50 <0.11 nM in Wnt-Luc reporter assay for Wnt pathway inhibition. Similar to IWP-2, IWP-3 and IWP-4, Wnt-C59 prevents palmitylation of Wnt proteins by Porcupine (Porcn, a membrane- bound O-acyltransferase), thereby blocking Wnt secretion and activity. What’s different is that Wnt-C59 not only shows 100-fold more potency and selectivity, but exhibits a better chemical and physical properties.Wnt-C59 is suitable for in vitro and in vivo studies [1,2].
Chemical Properties
| Cas No.: 1243243-89-1 |
M. Wt.: 379.45 |
| Formula: C25H21N3O |
Purity: >98% |
| Chemical Name: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide |
|
| Appearance: Pale yellow solid |
|
| Solubility: Soluble in DMSO (10 mM) |
|
| Storage: Store solid powder at 4 ºC desiccated, store DMSO stock solution at -20 ºC in small aliquots,prevent from repeat freeze/thaw cycles. |
|
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