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- IWN1007-0005MG
- 2025年11月09日
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- 详细信息
- 技术资料
- 保质期：
2 years
- 英文名：
IWR-1 endo
- 库存：
10
- 供应商：
上海伟进生物科技有限公司
- CAS号：
1127442-82-3
- 保存条件：
-20℃
- 规格：
5mg
Biological Activity
Two diastereomeric forms are synthesized in the production of IWR-1. IWR-1 endo is the purified “endo” form.
IWR-1 endo is a potent and cell-permeable inhibitor of Wnt response with an IC50 of 180 nM in a cell-based Wnt/β-catenin pathway reporter response. IWR-1 endo induces stabilization of Axin proteins via a direct interaction, accompanied by elevated levels of β-catenin phosphorylation, a prerequisite for proteasome-mediated destruction of β-catenin [1]. In in vivo experiments, IWR-1 endo inhibits zebrafish tail fin regeneration with a minimum inhibitory concentration of 0.5 μM. The compound shows a half-life of 60 minutes in murine whole blood and 20 minutes in intact murine hepatocytes [2]. The “exo” form of IWR-1 has a 25-fold less potency than endo-IWR, and often used as a specificity control for IWR-1 endo action.
Chemical Properties
| Cas No.: 1127442-82-3 |
M. Wt.: 409.44 |
| Formula: C25H19N3O3 |
Purity: ≥98% |
| Synonym: IWR-1-endo, endo IWR-1 |
|
| Chemical Name: [(3aR*,4S*,7R*,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide |
|
| Appearance: White to off-white solid |
|
| Solubility: Soluble in DMSO (20 mg/mL) |
|
| Storage: Store solid at -20 ºC for the stability of two years |
|
Application Concentration (Just for reference)
The appropriate working concentration of IWR-1 endo depends on cell types, cell culture properties and specific applications. It is recommended that researchers start with optimal experiments for first use.
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