Human interleukin 17 (IL-17), a novel cytokine discovered in 1995, is mainly secreted by activated CD4+T lymphocytes and can induce fibroblasts to support the growth of CD34+ hematopoietic progenitor cells and the proliferation and differentiation to neutrophils. The IL-17A~F family is based on IL-17, and the amino acids range from 150 to 180. All of them existed as covalent dimers except IL-17B. Interleukin 17 promotes Th1 and Th2 lymphocyte production and participates in T-cell-mediated skin immune responses by increasing IFN-γ and IL-4 induced activation of human keratinocytes. In vitro, IL-17 increased the expression of IL-6 and IL-8 in uterine cancer cell lines at the protein and mRNA levels, but had no direct effect on cell line proliferation in vitro. IL-17 is a pleiotropic factor that may promote or inhibit tumor growth depending on the immunogenicity of the tumor model. 仅供实验室使用。