KU-0058948

1) Cat. No.: TRC-K660400; 2) Chemical Name: KU-0058948 ; 3) CAS No.: 763111-49-5; 4) Mol. Formula: C21H21FN4O2; 5) Mol. Weight: 380.42; 6) Packing Size: 10mg / 100mg; 7) Appearence: Pale Yellow Solid; 8) Application Notes: KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary myeloid leukemic cells and myeloid leukemic cell lines in vitro; 9) Synonym: 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone; KU 0058948; KU0058948; 1-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepine;; 10) Solubility: DMSO, Methanol; 11) Storage condition: Refrigerator; 12) References: Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009); Gaymes, T.J. et al.: Haematologica, 94, 638 (2009);