K106389P-HRP Anti-GAPDH Polycl

【抗体靶点简介】

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities， thereby playing a role in glycolysis and nuclear functions， respectively. Participates in nuclear events including transcription， RNA transport， DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1， HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma treatment assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

抗体在科研领域应用十分广泛，对解析生物学过程、探究疾病发病机制、创新药物研发与临床治疗研究均起到关键支撑作用。

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