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- 文献和实验
- 技术资料
- 保存条件:
2-8度
- 保质期:
1年
- 英文名:
PEA15
- 库存:
999
- 供应商:
上海淳麦生物
- 规格:
/5ug/20ug/1mg
Recombinant Human Phosphoprotein Enriched in Astrocytes 15
英文简称:
PEA15
中文名称:
重组人星形胶质细胞丰富磷蛋白15
背景资料:
PEA15 (Phospho-enriched protein in astrocytes 15kDa) is a death e大肠杆菌中重组表达ector domain (DED)-containing protein mainly expressed in the central nervous system, principally in astrocytes. PEA15 is implicated in the regulation of various cellular processes including apoptosis, proliferation, glucose transport, adhesion and migration. PEA15 regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent tra大肠杆菌中重组表达icking of SLC2A4 from the cell interior to the surface. Increased PEA15 levels have an a大肠杆菌中重组表达ect tumorigenesis and cancer progression, therefore it is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm. In addition, PEA15 inhibits both TNFRSF6 and TNFRSF1A mediated CASP8 activity and apoptosis. PEA15 is ubiquitously expressed. PEA15 is most abundant in tissues such as the heart, brain, muscle and adipose tissue which use glucose as an energy source. Lower PEA15 expression is in glucose-producing tissues. Higher levels of PEA15 expression are found in tissues from individuals with type 2 diabetes than in controls. PEA15 expression is a significant prognostic marker in ovarian cancer.
产品描述:
PEA15 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 130 amino acids (1-130 a.a.) and having a molecular mass of 15kDa. The PEA15 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达
溶解建议:
Sterile Filtered colorless solution. The PEA15 protein solution contains 20mM Tris-HCl buffer (pH 7.5), 1mM DTT and 10% Glycerol.
保存建议:
PEA15 although stable 4℃ for 4 weeks, should be stored desiccated below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
应用领域:
重组人星形胶质细胞丰富磷蛋白15产品可广泛应用于功能研究、蛋白互作研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词:
重组人星形胶质细胞丰富磷蛋白15、Recombinant Human Phosphoprotein Enriched in Astrocytes 15、PEA15、重组蛋白、多肽、原核表达、CMBIO、淳麦生物
其他简介:
CMBIO




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