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- 文献和实验
- 技术资料
- 保存条件：
2-8度
- 保质期：
1年
- 英文名：
EDN1
- 库存：
999
- 供应商：
上海淳麦生物
- 规格：
/5ug/20ug/1mg
产品英文名称：
Human Endothelin-1
英文简称:
EDN1
中文名称:
人内皮素1
背景资料:
EDN1 is a powerful mitogen mediator of smooth muscle tone， and inflammatory regulator that is involved in diseases of the airways， pulmonary circulation， and inflammatory lung diseases， both acute and chronic. Endothelin-2 and Endothelin-3 vary from Endothelin-1 by two and six amino acids， respectively， and share homology， particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium， smooth muscle， airway epithelium， and a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2， & endothelin-3 （ET-3） consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells and tissues， particularly endothelial and epithelial lineages. These endothelins are derivatives from thrEDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton. genes. The endothelins are normally connected with hypertension， though they regulate a diversity of other eects through two G-protein coupled receptors， ET-A and ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes.
产品描述:
EDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton.
来源宿主:
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp.
溶解建议:
提供的人内皮素1产品为白色无菌冻干粉末，冻干粉里不含有其它添加剂.推荐使用无菌的18MΩ的超纯水来溶解，浓度不低于100ug/ml，便于后续稀释.
保存建议：
Lyophilized EDN1 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution EDN1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
应用领域：
人内皮素1产品可广泛应用于信号传导研究、药物靶点研究、毒理学研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
人内皮素1、Human Endothelin-1、EDN1、多肽、受体蛋白、毒素、CMBIO、淳麦生物
其他简介：
CMBIO
Human Endothelin-1
英文简称:
EDN1
中文名称:
人内皮素1
背景资料:
EDN1 is a powerful mitogen mediator of smooth muscle tone， and inflammatory regulator that is involved in diseases of the airways， pulmonary circulation， and inflammatory lung diseases， both acute and chronic. Endothelin-2 and Endothelin-3 vary from Endothelin-1 by two and six amino acids， respectively， and share homology， particularly at the carboxy terminus with sarafotoxins a-e. The lung has the largest levels of EDN1 secreted by endothelium， smooth muscle， airway epithelium， and a diversity of other cells. ET-1 also circulates in the plasma. Endothelin-1 along with endothelin-2， & endothelin-3 （ET-3） consist of the endothelin family of 21 amino acid peptides manufactured in a variety of cells and tissues， particularly endothelial and epithelial lineages. These endothelins are derivatives from thrEDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton. genes. The endothelins are normally connected with hypertension， though they regulate a diversity of other eects through two G-protein coupled receptors， ET-A and ET-B. The endothelins are derivatives from a precursor peptides using cleavage by metalloproteases for instance endothelin-converting enzymes.
产品描述:
EDN1 contains 21 amino acids having a molecular mass of 2491.95 Dalton.
来源宿主:
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp.
溶解建议:
提供的人内皮素1产品为白色无菌冻干粉末，冻干粉里不含有其它添加剂.推荐使用无菌的18MΩ的超纯水来溶解，浓度不低于100ug/ml，便于后续稀释.
保存建议：
Lyophilized EDN1 although stable at room temperature for 3 weeks， should be stored desiccated below -18℃. Upon reconstitution EDN1 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
应用领域：
人内皮素1产品可广泛应用于信号传导研究、药物靶点研究、毒理学研究、ELISA检测、Western Blot、免疫组化等生物医学研究领域。
关键词：
人内皮素1、Human Endothelin-1、EDN1、多肽、受体蛋白、毒素、CMBIO、淳麦生物
其他简介：
CMBIO
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文献和实验该产品被引用文献
Ilenia Masi et al. The extracellular matrix protein type I collagen and fibronectin are regulated b... J Exp Clin Cancer Res 2025. PMID:39985042
Maggie M Zhu et al. GCN2 kinase activation mediates pulmonary vascular remodeling and pulmonary arte... JCI Insight 2024. PMID:39316438
相关实验
大鼠 内皮素 1(ET-1) 酶联免疫分析 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定大鼠血清，血浆及相关液体样本中 内皮素1(ET-1) 的含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中大鼠 内皮素 1(ET-1) 水平。用纯化的大鼠 内皮素 1(ET-1) 抗体包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 内皮素 1(ET-1) 再与 HRP 标记的 ET-1 抗体
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表明，与免疫反应、细胞迁移、细胞增殖和血管生成受损、细胞外基质组织和缺氧反应相关的生物过程富集。研究者在独立的生物样品中，使用 qRT-PCR 验证了具有代表性的差异表达基因，包括编码内皮细胞分泌到细胞外空间的具有抗血管生成作用的蛋白质的基因（例如，Angpt2、Adamts1、Cxcl10 和 Thbs1），与细胞迁移和缺氧反应有关的因素（Edn1），干扰素反应基因（Iigp1）、细胞增殖抑制剂（Cdkn1a）和胚胎血管发育调节剂（Hey2）。 接下来，研究者在 Igf2EpiKO 模型中，检测
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文献支持
人内皮素1(EDN1)
￥700 - 1500
