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- 2026年07月07日
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- 文献和实验
- 技术资料
- CAS号：
54-31-9
- 规格：
1g/1mLx10mM(inDMSO)/500mg
| 规格： | 1g | 产品价格： | ￥333.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥306.0 |
| 规格： | 500mg | 产品价格： | ￥287.0 |
Product Introduction
Bioactivity
| 名称 | Furosemide |
| 描述 | Furosemide is a potent NKCC2 (Na-K-2Cl symporter) inhibitor, used for edema and chronic renal insufficiency. |
| 体外活性 | Furosemide reversibly alters the responses to tones and clicks of the chinchilla basilar membrane in hair cells, causing response-magnitude reductions that are largest (up to 61 dB, averaging 25-30 dB) at low stimulus intensities at the characteristic frequency (CF) and small or nonexistent at high intensities and at frequencies far removed from CF. Furosemide also induces response-phase lags that are largest at low stimulus intensities (averaging 77 degrees) and are confined to frequencies close to CF. [1] Furosemide concentration- and time-dependently increases the formation of nitric oxide andprostacyclin. Furosemide leads to an enhanced release of kinins into the supernatant of the cells. [2] Furosemide reversibly suppresses low Ca2+-induced epileptiform activity in hippocampus proper and blocks or significantly reduces different types of epileptiform discharges in the low Mg2+ model and the 4-aminopyridine model. [3] Furosemide significantly inhibits cell growth in MKN45 cells, but not in MKN28 cells. Furosemide diminishes cell growth by delaying the G(1)-S phase progression in poorly differentiated gastric adenocarcinoma cells, which show high expression and activity of NKCC, but not in moderately differentiated gastric adenocarcinoma cells with low expression and NKCC activity. [4] |
| 存储条件 | Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : < 10 mg/mL (30.23 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 252.5 mg/mL (763.43 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (30.23 mM), Solution. |
| 关键字 | γ-Aminobutyric acid Receptor | NKCC | NaKClcotransporter | Na-K-Cl cotransporter | NaKCl cotransporter | liver scarring | kidney disease | Inhibitor | inhibit | hypertension | heart failure | Gamma-aminobutyric acid Receptor | GABAReceptor | GABA Receptor | Furosemide | edema |
| 相关产品 | Penicillin G sodium salt | p-Hydroxybenzaldehyde | Valproic acid sodium salt | Valproic Acid | Methionine | Urethane | Methyl eugenol | Dihydromyricetin | (-)-α-Pinene | Imidazoleacetic acid hydrochloride | Baicalin | Nipecotic acid |
| 相关库 | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | FDA-Approved & Pharmacopeia Drug Library | Approved Drug Library | Ion Channel Targeted Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Human Metabolite Library | Anti-Cancer Drug Library | NMPA-Approved Drug Library |
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文献和实验30 4.18 3.59 3.25 3.03 2.87 2.75 2.65 2.57 2.51 2.41 2.31 2.19 2.07 1.94 1.79 30 31 4.16 3.57 3.23 3.01 2.85 2.73 2.63 2.56 2.49 2.40 2.29 2.18 2.06 1.92 1.77 31 32 4.15 3.56 3.22 2.99 2.84 2.71 2.62 2.54 2.48 2.38 2.27 2.16 2.04 1.90 1.75 32
49e/CD29、CD49f/CD29、CD51/CD29、CD11a/CD18、CD11b/CD18、CD11c/CD18、CD41/CD61、CD51/CD61、CD49f/CD104、CD2、CD4、CD8、CD28、CD31、CD50、CD54、CD56、CD58、CD80、CD102、CD106、CD62L、CD62P、CD62E、CD15、CD15s、CD44等。 （2）B表示CD命名范围中属IGSF结构的分子，如CD79a、CD79b、CD1、CD
71 07 32 90 79 78 53 13 55 38 58 59 88 97 54 14 10 4 12 56 85 99 26 96 96 68 27 31 05 03 72 93 15 57 12 10 14 21 88 26 49 81 76 5 55 59 56 35 64 38 54 82 46 22 31 62 43 09 90 06 18 44 32 53 23 83 01 30 30 6 16 22 77 94 39 49 54 43 54 82 17 37 93 23
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