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- T5939
- 2026年07月07日
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- CAS号：
20123-80-2
- 规格：
1mLx10mM(inDMSO)/1g/5g/10g/50mg/100mg/500mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥144.0 |
|---|---|---|---|
| 规格： | 1g | 产品价格： | ￥422.0 |
| 规格： | 5g | 产品价格： | ￥758.0 |
| 规格： | 10g | 产品价格： | ￥1056.0 |
| 规格： | 50mg | 产品价格： | ￥108.0 |
| 规格： | 100mg | 产品价格： | ￥138.0 |
| 规格： | 500mg | 产品价格： | ￥278.0 |
Product Introduction
Bioactivity
| 名称 | Calcium dobesilate |
| 描述 | Calcium dobesilate(CaD) has angioprotective properties and protects endothelial cells partly by ameliorating HG induced inflammation. |
| 细胞实验 | HUVECs were seeded in 96-well culture plates (1×10^4 cells/well). Following 24 h, the control or experimental medium was added. At 12, 24, 48 and 72 h, 10 μl CCK-8 reagent was added to each well for 1 h. Absorbance values were recorded at a wavelength of 450 nm using a microplate reader[1]. |
| 体外活性 | CaD inhibited abnormal cell proliferation. high glucose (HG) treatment also significantly enhanced HVUEC migration compared to the control treatment. In contrast, CaD treatment partially inhibited HUVEC migration compared to HG exposure. HG?treated HUVECs exhibited increased FITC?BSA permeability compared to control cells cultured in medium alone; however, CaD application prevented the HG?induced increase in FITC?BSA permeability and suppressed HG?induced overexpression of endothelial markers (VEGF, VEGFR?2, endocan) and inflammation markers (ICAM?1, MCP?1, PTX3) in HUVECs. CaD has angioprotective properties and protects endothelial cells partly by ameliorating HG?induced inflammation[1]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 50.00 mg/mL (119.50 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.00 mg/mL (4.78 mM), Sonication is recommended. |
| 关键字 | Inhibitor | inhibit | Calcium dobesilate | Apoptosis |
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羟苯磺酸钙【20123-80-2】
￥108 - 1056
