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- CAS号：
1056636-07-7
- 规格：
25mg
Product Introduction
Bioactivity
| 名称 | Momelotinib Mesylate |
| 描述 | Momelotinib Mesylate is an ATP-competitive JAK1/JAK2 inhibitor (IC50: 11 nM/18 nM). It has 10-fold selectivity versus JAK3. |
| 体外活性 | Momelotinib inhibits the proliferation of parental Ba/F3 cells (Ba/F3-wt) stimulated by IL-3 (IC50: 1400 nM) and it also inhibits PI3K/AKT and Ras/MAPK signaling induced by IL-6 and IGF-1. Momelotinib inhibits erythroid colony growth in vitro from JAK2V617F-positive PV patients with similar potency (IC50: 2 μM-4 μM) [1]. Momelotinib causes the inhibition of cell proliferation in cell lines constitutively activated by JAK2 or MPL signaling, including Ba/F3-MPLW515L cells, Ba/F3-TEL-JAK2 cells and CHRF-288-11 cells (IC50: 200 nM, 1 nM and 700 nM, respectively) and it also induces apoptosis as a single agent and synergizes with the conventional anti-MM therapies bortezomib and melphalan in primary multiple myeloma (MM) cells [2]. |
| 体内活性 | Momelotinib normalizes white cell counts, spleen size, hematocrit, in a murine MPN model. It also restores physiologic levels of inflammatory cytokines [3]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 关键字 | Momelotinib Mesylate | JAK3 | JAK2 | JAK1 | CYT-387 | CYT387 | CYT 387 |
| 相关产品 | Guanidine hydrochloride | Naringin | Enzalutamide | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Hemin | Hydroxychloroquine | Sildenafil citrate | Stavudine | Tamoxifen | Paeonol |
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]。 Section.07 Aβ 不是终点， 而是理解 AD 的钥匙 尽管近年靶向 Aβ 的抗体药物 (如 Lecanemab、Donanemab) 取得突破，但 AD 仍是多因素交织的复杂疾病。 Aβ 或许不只是 AD 的答案，但它很可能是最早被拉响的那声警报。 从 Aβ 生成、寡聚化，到激活胶质细胞、破坏突触、推动 tau 病变，再到线粒体崩溃与信号通路紊乱——这张精密的分子网络，正为我们指明干预的新靶点。 需要强调的是，Aβ 并非单一决定因素，而是 AD 病理级联反应中最早被系统
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化合物 Momelotinib Mesylate【1056636-07-7】
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