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- CAS号：
2135-17-3
- 规格：
1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥122.0 |
|---|---|---|---|
| 规格： | 5mg | 产品价格： | ￥111.0 |
| 规格： | 10mg | 产品价格： | ￥143.0 |
| 规格： | 25mg | 产品价格： | ￥210.0 |
| 规格： | 50mg | 产品价格： | ￥292.0 |
| 规格： | 100mg | 产品价格： | ￥434.0 |
| 规格： | 200mg | 产品价格： | ￥690.0 |
Product Introduction
Bioactivity
| 名称 | Flumethasone |
| 描述 | Flumethasone (RS-2177) is a glucocorticoid receptor agonist, with anti-inflammatory, antipruritic and vasoconstrictive properties. |
| 激酶实验 | Topoisomerase I Cleavable Complex Assay: Topoisomerase I is isolated from calf thymus and is devoid of topoisomerase II. All reactions are carried out in 10 mL volumes of reaction buffer (50 mM Tris-HCl, pH 7.5, 100 mM KCl, 0.5 mM EDTA, and 30 pg/mL BSA) in microtiter plates. Camptothecin is dissolved in DMSO at 10 mg/mL and serially diluted in 96-well microtiter plates to which the 32P end-labeled pBR322 DNA and topoisomerase enzyme are added. The reaction mixture is incubated at room temperature for 30 min and then the reaction stopped by adding 2 mL of a mixture of sodium dodecyl sulfate and proteinase K (1.6% and 0.14 mg/mL final concentrations, respectively). The plates are heated at 50 °C for 30 min, 10 mL of standard stop mixture containing 0.45 N NaOH is added in order to generate single-stranded DNA, and the samples are electrophoresed in 1.5% agarose gels in TBE buffer. Gels are blotted on nitrocellulose paper, dried, and exposed to X-ray film. The units of cleavage are calculated from the autoradiographs and plotted against the log drug concentration. The IC50 values are then obtaine |
| 体外活性 | 在患酮症的小牛中,Flumethasone（5 mg ）能够增加血浆葡萄糖浓度,降低血清β-羟基丁酸和尿乙酰乙酸浓度,同时能够改善子宫疾病.在患严重急性支气管肺炎小牛中,Flumethasone与头孢噻呋钠联用,能够使生理指标回到正常水平,提高生存率. |
| 存储条件 | Keep away from moisture,Store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 55 mg/mL (134 mM), Sonication is recommended. Ethanol : 6 mg/mL (14.62 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.87 mM), Sonication is recommended. |
| 关键字 | RS2177 | RS 2177 | NSC54702 | NSC 54702 | Inhibitor | inhibit | GlucocorticoidReceptor | Glucocorticoid Receptor | Flumethasone |
| 相关产品 | Rhamnose monohydrate | Kaolin | Magnesium acetate tetrahydrate | Aceglutamide | Calcium Propionate | Benzyl propionate | Terbinafine hydrochloride | Geraniol | Gluconate Calcium | D(+)-Raffinose pentahydrate | Hydroxypropyl Cellulose | Sodium formate |
| 相关库 | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Anti-Cancer Compound Library | Anti-Fungal Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Fluorochemical Library | Anti-Aging Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library |
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￥111 - 690
