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- CAS号：
19387-91-8
- 规格：
1g/1mLx10mM(inDMSO)/5g/10g/50mg/100mg/500mg
| 规格： | 1g | 产品价格： | ￥396.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥143.0 |
| 规格： | 5g | 产品价格： | ￥794.0 |
| 规格： | 10g | 产品价格： | ￥1176.0 |
| 规格： | 50mg | 产品价格： | ￥114.0 |
| 规格： | 100mg | 产品价格： | ￥146.0 |
| 规格： | 500mg | 产品价格： | ￥294.0 |
Product Introduction
Bioactivity
| 名称 | Tinidazole |
| 描述 | Tinidazole (CP12574)a is a 5-nitroimidazole derivative with the antiprotozoal property. Although the mechanism of action has not been fully elucidated, it has been suggested that tinidazole is metabolized and yields nitrite anions and metronidazole. Metronidazole's nitro group, in turn, is reduced via the parasite ferredoxin, thereby generating a series of free nitro radicals including nitro anions. Toxicity is achieved via depletion of sulfhydryl groups and DNA strand breaks with multiple hits having an additive effect and ultimately leading to cell death. |
| 体内活性 | Tinidazole对多种细菌均有抗菌作用,如：广泛的临床明显厌氧细菌（Bacteroides fragilis, Clostridium difficile等）,致病性原生动物（Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis等）和微需氧的幽门螺杆菌。 Tinidazole对10种Prevotella bivia,11种Bacteroides fragilis和40种Clostridium difficile临床分离株有活性,Tinidazole和甲硝唑的平均MIC分别是： C. difficile,0.31 μg/mL和0.28 μg/mL;B. fragilis,0.5 μg/mL和0.71 μg/mL; P. bivia,2.33 μg/mL与1.52 μg/mL。在敏感细菌细胞和原生动物中,Tinidazole被还原为细胞毒性中间体,与DNA共价结合,导致细胞不可逆损伤。在低MLC时Tinidazole可杀死甲硝唑敏感株,但只对12甲硝唑耐药株中的4株有效。 Tinidazole对104 种T. vaginalis分离株均有抑制,平均MLC为1014.9 μM。Tinidazole影响滋养体对Giardia duodenalis的形态,可行性和依从性。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Saline : 7.43 mg/mL (30.05 mM), Solution. DMSO : 74.29 mg/mL (300.44 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (10.11 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) |
| 关键字 | Tinidazole | Inhibitor | inhibit | infections | CP-12574 | CP 12574 | Bacterial | bacteria | antimicrobial | Antibiotic | anaerobic |
| 相关产品 | 2-Amino-2-methyl-1-propanol | Fenpyroximate | Levulinic acid | Neomycin sulfate | Terbinafine hydrochloride | Hydroxychloroquine | Dimethyl sulfoxide | Sodium bicarbonate | Hyaluronic acid sodium (MW 20 kDa) | Sodium diacetate | Sulfamethoxazole sodium | D(+)-Raffinose pentahydrate |
| 相关库 | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | Anti-Bacterial Compound Library | Antibiotics Library | Approved Drug Library | Anti-COVID-19 Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Anti-Parasitic Compound Library | Orally Active Compound Library | Drug Repurposing Compound Library |
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替硝唑【19387-91-8】
￥114 - 1176
