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- T7982
- 2026年07月07日
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- 详细信息
- 文献和实验
- 技术资料
- CAS号：
108238-41-1
- 规格：
1mLx10mM(inDMSO)/10mg/25mg/50mg/100mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥95.0 |
|---|---|---|---|
| 规格： | 10mg | 产品价格： | ￥111.0 |
| 规格： | 25mg | 产品价格： | ￥210.0 |
| 规格： | 50mg | 产品价格： | ￥309.0 |
| 规格： | 100mg | 产品价格： | ￥436.0 |
Product Introduction
Bioactivity
| 名称 | 3,6-Dihydroxyflavone |
| 描述 | 3,6-Dihydroxyflavone suppresses the epithelial-mesenchymal transition in breast cancer cells by inhibiting the Notch signaling pathway. |
| 细胞实验 | Cells were cultured in six-well plates until they reached 100% confluence. A vertical or horizontal wound was gently created in monolayers using a 20 μl sterile pipette tip. The cells were then washed for 3 times with growth medium to remove the detached cells, and the medium was added with fresh medium treated with 3,6-DHF. Images were captured using an inverted microscope and camera at designed times to assess the inhibition of wound closure[1]. |
| 体外活性 | 3,6-Dihydroxyflavone（3,6-DHF）能有效抑制体外和体内乳腺癌（BC）细胞的上皮间质转化（EMT）。研究表明，3,6-DHF有效抑制乳腺癌干细胞（BCSCs）的形成和增殖，从而降低了小鼠NOD/SCID中肿瘤细胞的肿瘤形成能力。体内光学成像显示，3,6-DHF治疗抑制了乳腺癌细胞在体内的肺转移。进一步研究指出，3,6-DHF通过下调Notch1、NICD、Hes-1和c-Myc，减少NICD-CSL-MAML功能性转录单元的形成，从而导致乳腺癌细胞中Notch信号通路的失活。Notch1的过度表达或miR-34a的抑制显著降低了3,6-DHF对EMT、CSCs以及乳腺癌细胞迁移和侵袭的抑制作用。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : 250 mg/mL (983.32 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (39.33 mM), Solution. 10% DMSO+90% Saline : < 10 mg/mL (39.33 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. |
| 关键字 | PARP | oxidative stress | lipid peroxidation | Inhibitor | inhibit | cell viability | caspase cascade | Apoptosis | 3,6-Dihydroxyflavone | 3,6Dihydroxyflavone | 3,6-DHF | 3,6 Dihydroxyflavone |
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文献和实验3.82 3.47 3.25 3.09 2.97 2.87 2.80 2.73 2.64 2.53 2.42 2.31 2.18 2.04 21 22 4.38 3.73 3.44 3.21 3.05 2.93 2.84 2.76 2.70 2.60 2.50 2.39 2.27 2.14 2.00 22 23 4.35 3.75 3.41 3.18 3.02 2.90 2.81 2.73 2.67 2.57 2.47 2.36 2.24 2.11 1.97 23 24
98 29 38 23 16 86 38 42 38 97 01 50 87 75 66 81 41 40 01 74 91 62 48 51 84 08 32 30 31 96 25 91 47 96 44 33 49 13 34 86 82 53 91 00 52 43 48 85 27 55 26 89 62 31 66 67 40 67 14 64 05 71 95 86 11 05 65 09 68 76 83 20 37 90 57 16 00 11 66 32 14 90
3.76 3.75 3.74 3.72 3.71 3.69 3.68 3.67 6 7 3.43 3.41 3.40 3.39 3.38 3.36 3.34 3.33 3.32 3.30 3.29 3.27 3.25 3.24 3.23 7 8 3.13 3.12 3.10 3.09 3.08 3.06 3.04 3.03 3.02 3.01 2.99 2.97 2.95 2.94 2.93 8 9 2.92 2.90 2.89 2.87 2.83 2.84 2.83 2.81 2.80
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