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- CAS号：
41964-07-2
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥153.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥334.0 |
| 规格： | 5mg | 产品价格： | ￥318.0 |
| 规格： | 10mg | 产品价格： | ￥455.0 |
| 规格： | 25mg | 产品价格： | ￥789.0 |
| 规格： | 50mg | 产品价格： | ￥1240.0 |
| 规格： | 100mg | 产品价格： | ￥1864.0 |
| 规格： | 200mg | 产品价格： | ￥2768.0 |
Product Introduction
Bioactivity
| 名称 | Tolimidone |
| 描述 | Tolimidone (NSC 314335) is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
| 细胞实验 | Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference) |
| 体外活性 | In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism[1]. |
| 体内活性 | MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity[1]. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals[2]. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (9.89 mM), Sonication is recommended. DMSO : 125 mg/mL (618.17 mM), Sonication is recommended. 10% DMSO+90% Saline : 10 mg/mL (49.45 mM), Solution. Ethanol : 4 mg/mL (19.78 mM), Sonication is recommended. |
| 关键字 | Tolimidone | Src | NSC-314335 | NSC314335 | MLR1023 | MLR 1023 | Lyn kinase | Inhibitor | inhibit | CP26154 | CP 26154 |
| 相关产品 | Pelitinib | MCB-613 | Dasatinib monohydrate | SI-2 hydrochloride | Vemurafenib | TAK-901 | Tofacitinib | Staurosporine | Dasatinib | Nintedanib | Ibrutinib | iHCK-37 |
| 相关库 | Bioactive Compound Library | Anti-Cancer Compound Library | Bioactive Compounds Library Max | Anti-Cancer Metabolism Compound Library | Mitochondria-Targeted Compound Library | Anti-Infection Compound Library | Kinase Inhibitor Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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托利咪酮【41964-07-2】
￥153 - 2768
