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- 2026年07月07日
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- CAS号：
1445993-26-9
- 规格：
1mg/1mLx10mM(inDMSO)/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mg | 产品价格： | ￥281.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥636.0 |
| 规格： | 5mg | 产品价格： | ￥629.0 |
| 规格： | 10mg | 产品价格： | ￥1024.0 |
| 规格： | 25mg | 产品价格： | ￥2120.0 |
| 规格： | 50mg | 产品价格： | ￥3184.0 |
| 规格： | 100mg | 产品价格： | ￥4392.0 |
| 规格： | 200mg | 产品价格： | ￥6144.0 |
Product Introduction
Bioactivity
| 名称 | Mivebresib |
| 描述 | Mivebresib (ABBV-075), also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration, the bromodomain inhibitor ABBV-075 binds to the acetyl-lysine binding site in the BRD of certain BRD-containing protein(s), thereby preventing the interaction between those proteins and acetylated histones. This disrupts chromatin remodeling, prevents the expression of certain growth-promoting genes, and leads to an inhibition of cell growth in susceptible tumors. Also a potent inhibitor of MYC and the TMPRSS2-ETS fusion proteins. |
| 体外活性 | Mivebresib在来源于实体瘤、白血病和淋巴瘤的癌症细胞系上的细胞活性检测中展示活性。它能够干扰细胞周期控制，导致G1期阻滞后进入衰老状态，抑制致癌因子从而触发凋亡，并有可能针对肿瘤微环境以提供额外治疗效益[1]。 |
| 体内活性 | ABBV-075在非小细胞肺癌、小细胞肺癌、胰腺癌、乳腺癌、前列腺癌、头颈癌、多发性骨髓瘤、弥漫大B细胞淋巴瘤和白血病的侧腹移植小鼠模型中，与标准治疗药物相比，具有相当或更优的疗效[1]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | H2O : < 1 mg/mL (insoluble or slightly soluble) 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 10 mg/mL (21.76 mM), Suspension. 10% DMSO+90% Saline : < 10 mg/mL (21.76 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 250 mg/mL (544.11 mM), Sonication is recommended. |
| 关键字 | Mivebresib | Inhibitor | inhibit | EpigeneticReaderDomain | Epigenetic Reader Domain | BET | Apoptosis | ABBV075 | ABBV 075 |
| 相关产品 | Formamide | Urea | Sodium Molybdate | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Citric Acid Triammonium | Stavudine | Tamoxifen |
| 相关库 | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | Chromatin Modification Compound Library | Failed Clinical Trials Compound Library | Highly Selective Inhibitor Library | Anti-Aging Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Target-Focused Phenotypic Screening Library | Anti-Cancer Drug Library |
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米维布塞【1445993-26-9】
￥281 - 6144
