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- TargetMol
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- 2026年07月07日
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- CAS号：
6754-58-1
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg/100mg/200mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥359.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥214.0 |
| 规格： | 5mg | 产品价格： | ￥462.0 |
| 规格： | 10mg | 产品价格： | ￥713.0 |
| 规格： | 25mg | 产品价格： | ￥1456.0 |
| 规格： | 50mg | 产品价格： | ￥2176.0 |
| 规格： | 100mg | 产品价格： | ￥3176.0 |
| 规格： | 200mg | 产品价格： | ￥4464.0 |
Product Introduction
Bioactivity
| 名称 | Xanthohumol |
| 描述 | Xanthohumol, also known as 2', 4, 4'-trihydroxy-6'-methoxy-3'-prenylchalcone or desmethylxanthohumol, is a member of the class of compounds known as 3-prenylated chalcones. It inhibits COX-1 and COX-2 activity and shows chemopreventive effects. |
| 细胞实验 | HL-60 cells are maintained in RPMI 1640 supplemented with 10% FBS at 37°C in a 5% CO2 atmosphere. Log-phase cells with a population doubling time of 14–16 h are used for experiments. Serial 2-fold dilutions of compounds (dissolved in DMSO, final concentration 0.1%) in a final concentration range of 0.2–12.5 μM are prepared in 24-well plates using 1 ml of RPMI/well. Control wells obtain the same amount of solvent. Subsequently, 1 ml of the cell suspension is added to the wells. After 96 h, the experiment is evaluated. Cell numbers are counted using a Casy 1 TTC flow-cytometer. The proliferation of treated cells is expressed as a percentage in comparison with the solvent control.(Only for Reference) |
| 激酶实验 | Inhibition of Cox Activity: Inhibition of Cox-1 activity is measured by monitoring oxygen consumption during the conversion of arachidonic acid to PGs using a Clark-type O2-electrode. The reaction mixture contains ～0.2 units Cox-1 in 100 μL of microsome fraction derived from ram seminal vesicles as a crude source of Cox-1 (specific activity 0.2–1 units/mg protein) or 0.23 units of recombinant human Cox-2 (specific activity 43 units/mg protein). For calculation, the rate of O2 consumption is compared with a DMSO control (100% activity). Piroxicam, a nonsteroidal anti-inflammatory drug, is used as positive inhibitory substance for Cox-1 activity with an IC50 of 0.35 ± 0.05 μM (n = 2). Alternatively, nimesulide, a Cox-2 specific inhibitor, inhibits Cox-2 activity by 52 ± 5.7% (n = 2) at a concentration of 50 μM. |
| 体外活性 | Xanthohumol抑制小鼠肝癌细胞培养中的Cyp1A活性并诱导QR活性。Xanthohumol清除活性氧物种，抑制超氧阴离子自由基和一氧化氮的产生。此外，Xanthohumol通过抑制DNA合成、诱导细胞周期在S期停滞、凋亡及细胞分化来阻止癌症的发生。[1] Xanthohumol还显示出强大的抗HIV-1活性。[2] |
| 体内活性 | 在CETP-Tg小鼠中，黄腐酚（p.o.）阻止胆固醇积聚导致动脉粥样硬化。[3] 在TRAMP小鼠中，黄腐酚（p.o.）促成尿生殖道（UG）平均重量下降, 延缓高级肿瘤进展并抑制低分化前列腺癌的生长。[4] |
| 存储条件 | Keep away from moisture,Keep away from direct sunlight,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 35.40 mg/mL (99.89 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4.00 mg/mL (11.29 mM), Sonication is recommended. DMSO : 150.00 mg/mL (423.25 mM), Sonication is recommended. |
| 关键字 | Xanthohumol | mono- acylglycerol acyltransferase | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | HSV | Herpes simplex virus | Diglyceride acyltransferase | Diacylglycerol acyltransferase | Cytomegalovirus | Cyclooxygenase | COX | CMV | Apoptosis | Acyltransferase | acyl-CoA:cholesterol acyltransferase |
| 相关产品 | Trometamol | Formamide | Urea | Dimethyl phthalate | Aceglutamide | Alginic acid | Cysteamine hydrochloride | Metronidazole | Sildenafil citrate | Stavudine | Tamoxifen | Thymidine |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Flavonoid Natural Product Library | Food as Medicine Compound Library | Anti-Aging Compound Library | Anti-Tumor Natural Product Library | Flavor Natural Product library | Anti-virus Traditional Chinese Medicine Monomer Library | Pain-Related Compound Library | Anti-Cancer Clinical Compound Library | Polyphenolic Natural Product Library | Anti-Cancer Drug Library |
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￥214 - 4464
