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- CAS号：
161973-10-0
- 规格：
1g/1mLx10mM(inDMSO)/25mg/50mg/100mg/500mg
| 规格： | 1g | 产品价格： | ￥976.0 |
|---|---|---|---|
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥172.0 |
| 规格： | 25mg | 产品价格： | ￥153.0 |
| 规格： | 50mg | 产品价格： | ￥212.0 |
| 规格： | 100mg | 产品价格： | ￥287.0 |
| 规格： | 500mg | 产品价格： | ￥662.0 |
Product Introduction
Bioactivity
| 名称 | Esomeprazole Magnesium |
| 描述 | Esomeprazole Magnesium (NEXIUM) is the S-isomer of omeprazole, can reduce gastric acid secretion with selective and irreversible proton pump inhibitor activity.Esomeprazole magnesium acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases |
| 激酶实验 | Purified enzyme assays: ATM for use in the in vitro assay is obtained from HeLa nuclear extract by immunoprecipitation with rabbit polyclonal antiserum raised to the COOH-terminal 400 amino acids of ATM in buffer containing 25 mM HEPES (pH 7.4), 2 mM MgCl2, 250 mM KCl, 500 μM EDTA, 100 μM Na3VO4, 10% v/v glycerol, and 0.1% v/v Igepal. ATM-antibody complexes are isolated from nuclear extract by incubating with protein A-Sepharose beads for 1 hour and then through centrifugation to recover the beads. In the well of a 96-well plate, ATM-containing Sepharose beads are incubated with 1 μg of substrate glutathione S-transferase–p53N66 (NH2-terminal 66 amino acids of p53 fused to glutathione S-transferase) in ATM assay buffer [25 mM HEPES (pH 7.4), 75 mM NaCl, 3 mM MgCl2, 2 mM MnCl2, 50 μM Na3VO4, 500 μM DTT, and 5% v/v glycerol] at 37 °C in the presence or absence of inhibitor. After 10 minutes with gentle shaking, ATP is added to a final concentration of 50 μM and the reaction continued at 37 °C for an additional 1 hour. The plate is centrifuged at 250 × g for 10 minutes (4 °C) to remove the ATM-containing beads, and the supernatant is removed and transferred to a white opaque 96-well plate and incubated at room temperature for 1.5 hours to allow glutathione S-transferase-p53N66 binding. This plate is then washed with PBS, blotted dry, and analyzed by a standard ELISA technique with a phospho-serine 15 p53 antibody. The detection of phosphorylated glutathione S-transferase-p53N66 substrate is performed in combination with a goat antimouse horseradish peroxidase-conjugated secondary antibody. Enhanced chemiluminescence solution is used to produce a signal and chemiluminescent detection is carried out. |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | Ethanol : 143 mg/mL (200.53 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) DMSO : 45 mg/mL (63.1 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (2.8 mM), Sonication is recommended. |
| 关键字 | Protonpump | Proton Pump | Omeprazole magnesium | K+-ATPase | intestinal | Inhibitor | inhibit | H+/K+-ATPase | Esomeprazole Magnesium | Esomeprazole | disorders | Cu/Zn-superoxide | antioxidant | (S)-Omeprazole |
| 相关产品 | Chlorpropamide | Sodium orthovanadate | 2,3-Butanedione 2-Monoxime | Omeprazole | Oleic acid | Revaprazan hydrochloride | Lansoprazole | Abscisic Acid | Permethrin | Zinc pyrithione | trans-Aconitic acid | Sodium oleate |
| 相关库 | Inhibitor Library | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | EMA Approved Drug Library | FDA-Approved Drug Library | Membrane Protein-targeted Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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埃索美拉唑镁【161973-10-0】
￥153 - 976
