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- CAS号：
126544-47-6
- 规格：
1mLx10mM(inDMSO)/1mg/5mg/10mg/25mg/50mg
| 规格： | 1mLx10mM(inDMSO) | 产品价格： | ￥252.0 |
|---|---|---|---|
| 规格： | 1mg | 产品价格： | ￥119.0 |
| 规格： | 5mg | 产品价格： | ￥217.0 |
| 规格： | 10mg | 产品价格： | ￥328.0 |
| 规格： | 25mg | 产品价格： | ￥598.0 |
| 规格： | 50mg | 产品价格： | ￥952.0 |
Product Introduction
Bioactivity
| 名称 | Ciclesonide |
| 描述 | Ciclesonide (Alvesco)(RPR251526) is a glucocorticoid used for the treatment of obstructive airway diseases. |
| 细胞实验 | Metabolism of ciclesonide: After initial cultivation, A549 cells are washed five times with 10 ml/dish sterile PBS. An ethanolic stock solution of ciclesonide is diluted 1000-fold with assay medium to generate the initial ciclesonide concentration. The cells are incubated for 1 h in DMEM/0.1% (w/v) BSA (5 ml/dish) containing 0.02 μM ciclesonide as described above in a CO2 incubator. At the end of the incubation period, dishes are washed five times with PBS and incubated for 3, 6, or 24 h at the same conditions in 5 ml/dish fresh medium (DMEM/0.1% (w/v) BSA). At each indicated time point, the medium is removed by aspiration, 5 mM EDTA-4Na/PBS added and dishes are incubated for further 5 min. The cells are detached from the dishes and harvested. Each dish is washed five times with icechilled PBS. (Only for Reference) |
| 体外活性 | Ciclesonide 在人类肺泡II型上皮细胞(A549)中得到有效摄取并转化为其药理活性代谢物des-CIC及desCIC的脂肪酸缀合物[2]。 |
| 存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | 10% DMSO+90% Corn oil : 10 mg/mL (18.49 mM), Solution. Ethanol : 54.1 mg/mL (100.06 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : < 10 mg/mL (18.49 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+90% Saline : < 10 mg/mL (18.49 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. 10% DMSO+90% (20% SBE-β-CD in Saline) : < 10 mg/mL (18.49 mM), Lower concentrations may be soluble, but exact solubility limit is unknown. DMSO : 250 mg/mL (462.37 mM), Sonication is recommended. |
| 关键字 | RPR-251526 | RPR 251526 | Inhibitor | inhibit | GlucocorticoidReceptor | Glucocorticoid Receptor | Ciclesonide |
| 相关产品 | Dexamethasone Phosphate disodium | Megestrol acetate | Prednisone acetate | Prednisolone acetate | Mifepristone | Dexamethasone acetate | Betamethasone dipropionate | Dexamethasone | Betamethasone | Beclometasone | Nimodipine | Cortisone |
| 相关库 | Bioactive Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | ReFRAME Related Library | Anti-Aging Compound Library | Approved Drug Library | NO PAINS Compound Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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￥119 - 952
