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- 2026年07月07日
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- CAS号：
157716-52-4
- 规格：
1mg/2mg/5mg/10mg/25mg/50mg/100mg
| 规格： | 1mg | 产品价格： | ￥282.0 |
|---|---|---|---|
| 规格： | 2mg | 产品价格： | ￥382.0 |
| 规格： | 5mg | 产品价格： | ￥647.0 |
| 规格： | 10mg | 产品价格： | ￥1104.0 |
| 规格： | 25mg | 产品价格： | ￥1944.0 |
| 规格： | 50mg | 产品价格： | ￥2864.0 |
| 规格： | 100mg | 产品价格： | ￥4144.0 |
Product Introduction
Bioactivity
| 名称 | Perifosine |
| 描述 | Perifosine (KRX-0401) is an oral-active, alkyl-phosphocholine Akt inhibitor with potential antineoplastic activity. |
| 细胞实验 | Cells are incubated in the medium with 10% FCS for 48 hours with indicated concentration of Periosine. Cell viability is determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. (Cell Proliferation Kit I; Roche). The absorbance at 590 nm is recorded using the 96-well plate reader.(Only for Reference) |
| 激酶实验 | Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit. |
| 体外活性 | 在神经胶质瘤中,Perifosine激活Akt和Ras-ERK1/2途径.Perifosine诱导血小板和白细胞增多,导致移植骨髓瘤的凋亡. |
| 体内活性 | 在MM.1S细胞中,Perifosine（10 μM ）能够完全抑制Akt的磷酸化。在永生化角质形成细胞和头颈部鳞状癌细胞中（IC50=0.6-8.9 μM）,Perifosine抑制细胞增殖。在小鼠的神经胶质祖细胞中,Perifosine通过减少Akt的磷酸化水平和细胞外信号调节激酶,诱导细胞周期停滞在G1和G2,引起细胞生长抑制。在人类肝癌细胞中,Perifosine通过阻断Akt的磷酸化,诱导细胞周期停滞和细胞凋亡。 |
| 存储条件 | Keep away from moisture,Store at low temperature,Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
| 溶解度 | DMSO : Insoluble H2O : 10 mM, Sonication is recommended. |
| 关键字 | Protein kinase B | PKB | Perifosine | NSC-639966 | NSC639966 | KRX0401 | KRX 0401 | Inhibitor | inhibit | D-21266 | D 21266 | Autophagy | Apoptosis | Akt |
| 相关产品 | Formamide | Urea | Guanidine hydrochloride | Naringin | Aceglutamide | Alginic acid | Metronidazole | Hemin | Hydroxychloroquine | Stavudine | Paeonol | Ethyl linoleate |
| 相关库 | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library | Bioactive Compounds Library Max | ReFRAME Related Library | Kinase Inhibitor Library | Anti-Aging Compound Library | Anti-Lung Cancer Compound Library | Immunology/Inflammation Compound Library | Drug Repurposing Compound Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Drug Library |
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￥282 - 4144
